Skip to main content
Fig. 1 | Cancer & Metabolism

Fig. 1

From: Lactate/pyruvate transporter MCT-1 is a direct Wnt target that confers sensitivity to 3-bromopyruvate in colon cancer

Fig. 1

Blocking Wnt with dnLEF-1 reduces MCT-1 but not MCT-4 levels. qRT-PCR analysis was performed on RNA collected from SW480 (a) and SW620 (b) cells stably expressing dnLEF-1. Analysis was also performed for HCT116 cells (c) 72 h after lentiviral transduction of dnLEF-1 and DLD-1 dnLEF-1 cells (d) harvested 72 h after the addition of doxycycline. Graphs shown represent the average of three trials (+/− SEM). Whole cell lysates from each cell line (a–d) were harvested concurrently with RNA and were probed with the antibodies shown. (*p value <0.05; **p value < 0.01; ***p value < 0.001)

Back to article page

Cancer & Metabolism

ISSN: 2049-3002