TY - JOUR AU - Reya, T. AU - Clevers, H. PY - 2005 DA - 2005// TI - Wnt signalling in stem cells and cancer JO - Nature VL - 434 UR - https://doi.org/10.1038/nature03319 DO - 10.1038/nature03319 ID - Reya2005 ER - TY - JOUR AU - Bienz, M. AU - Clevers, H. PY - 2000 DA - 2000// TI - Linking colorectal cancer to Wnt signaling review JO - Cell VL - 103 UR - https://doi.org/10.1016/S0092-8674(00)00122-7 DO - 10.1016/S0092-8674(00)00122-7 ID - Bienz2000 ER - TY - JOUR AU - Klaus, A. AU - Birchmeier, W. PY - 2008 DA - 2008// TI - Wnt signalling and its impact on development and cancer JO - Nat Rev Cancer VL - 8 UR - https://doi.org/10.1038/nrc2389 DO - 10.1038/nrc2389 ID - Klaus2008 ER - TY - JOUR AU - Clevers, H. PY - 2006 DA - 2006// TI - Wnt/beta-catenin signaling in development and disease JO - Cell VL - 127 UR - https://doi.org/10.1016/j.cell.2006.10.018 DO - 10.1016/j.cell.2006.10.018 ID - Clevers2006 ER - TY - JOUR AU - Wetering, M. PY - 2002 DA - 2002// TI - The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells JO - Cell VL - 111 UR - https://doi.org/10.1016/S0092-8674(02)01014-0 DO - 10.1016/S0092-8674(02)01014-0 ID - Wetering2002 ER - TY - JOUR AU - Hoverter, N. P. AU - Ting, J. -. H. AU - Sundaresh, S. AU - Baldi, P. AU - Waterman, M. L. PY - 2012 DA - 2012// TI - A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs JO - Mol Cell Biol VL - 32 UR - https://doi.org/10.1128/MCB.06769-11 DO - 10.1128/MCB.06769-11 ID - Hoverter2012 ER - TY - JOUR AU - Brabletz, T. PY - 2005 DA - 2005// TI - Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin JO - Cells Tissues Organs VL - 179 UR - https://doi.org/10.1159/000084509 DO - 10.1159/000084509 ID - Brabletz2005 ER - TY - JOUR AU - Pate, K. T. PY - 2014 DA - 2014// TI - Wnt signaling directs a metabolic program of glycolysis and angiogenesis in colon cancer JO - EMBO J VL - 33 ID - Pate2014 ER - TY - JOUR AU - Schuijers, J. AU - Mokry, M. AU - Hatzis, P. AU - Cuppen, E. AU - Clevers, H. PY - 2014 DA - 2014// TI - Wnt-induced transcriptional activation is exclusively mediated by TCF/LEF JO - EMBO J VL - 33 UR - https://doi.org/10.1002/embj.201385358 DO - 10.1002/embj.201385358 ID - Schuijers2014 ER - TY - JOUR AU - Batlle, E. PY - 2002 DA - 2002// TI - β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/EphrinB JO - Cell VL - 111 UR - https://doi.org/10.1016/S0092-8674(02)01015-2 DO - 10.1016/S0092-8674(02)01015-2 ID - Batlle2002 ER - TY - JOUR AU - Izumi, H. PY - 2011 DA - 2011// TI - Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells JO - Cancer Sci VL - 102 UR - https://doi.org/10.1111/j.1349-7006.2011.01908.x DO - 10.1111/j.1349-7006.2011.01908.x ID - Izumi2011 ER - TY - JOUR AU - Pinheiro, C. PY - 2012 DA - 2012// TI - Role of monocarboxylate transporters in human cancers: state of the art JO - J Bioenerg Biomembr VL - 44 UR - https://doi.org/10.1007/s10863-012-9428-1 DO - 10.1007/s10863-012-9428-1 ID - Pinheiro2012 ER - TY - JOUR AU - Halestrap, A. P. PY - 2013 DA - 2013// TI - Monocarboxylic acid transport JO - Compr Physiol VL - 3 UR - https://doi.org/10.1002/cphy.c130008 DO - 10.1002/cphy.c130008 ID - Halestrap2013 ER - TY - JOUR AU - Halestrap, A. P. AU - Wilson, M. C. PY - 2012 DA - 2012// TI - The monocarboxylate transporter family—role and regulation JO - IUBMB Life VL - 64 UR - https://doi.org/10.1002/iub.572 DO - 10.1002/iub.572 ID - Halestrap2012 ER - TY - JOUR AU - Majumdar, S. AU - Gunda, S. AU - Pal, D. AU - Mitra, A. K. PY - 2005 DA - 2005// TI - Functional activity of a monocarboxylate transporter, MCT1, in the human retinal pigmented epithelium cell line, ARPE-19 JO - Mol Pharm VL - 2 UR - https://doi.org/10.1021/mp0499050 DO - 10.1021/mp0499050 ID - Majumdar2005 ER - TY - JOUR AU - Benton, C. R. PY - 2008 DA - 2008// TI - PGC-1alpha increases skeletal muscle lactate uptake by increasing the expression of MCT1 but not MCT2 or MCT4 JO - Physiol Genomics VL - 35 UR - https://doi.org/10.1152/physiolgenomics.90217.2008 DO - 10.1152/physiolgenomics.90217.2008 ID - Benton2008 ER - TY - JOUR AU - Galardo, M. N. AU - Riera, M. F. AU - Pellizzari, E. H. AU - Cigorraga, S. B. AU - Meroni, S. B. PY - 2007 DA - 2007// TI - The AMP-activated protein kinase activator, 5-aminoimidazole-4-carboxamide-1-b-D-ribonucleoside, regulates lactate production in rat Sertoli cells JO - J Mol Endocrinol VL - 39 UR - https://doi.org/10.1677/JME-07-0054 DO - 10.1677/JME-07-0054 ID - Galardo2007 ER - TY - JOUR AU - Cuff, M. A. AU - Lambert, D. W. AU - Shirazi-Beechey, S. P. PY - 2002 DA - 2002// TI - Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1 JO - J Physiol VL - 539 UR - https://doi.org/10.1113/jphysiol.2001.014241 DO - 10.1113/jphysiol.2001.014241 ID - Cuff2002 ER - TY - JOUR AU - Perez de Heredia, F. AU - Wood, I. S. AU - Trayhurn, P. PY - 2010 DA - 2010// TI - Hypoxia stimulates lactate release and modulates monocarboxylate transporter (MCT1, MCT2, and MCT4) expression in human adipocytes JO - Pflugers Arch VL - 459 UR - https://doi.org/10.1007/s00424-009-0750-3 DO - 10.1007/s00424-009-0750-3 ID - Perez de Heredia2010 ER - TY - JOUR AU - Ullah, M. S. AU - Davies, A. J. AU - Halestrap, A. P. PY - 2006 DA - 2006// TI - The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism JO - J Biol Chem VL - 281 UR - https://doi.org/10.1074/jbc.M511397200 DO - 10.1074/jbc.M511397200 ID - Ullah2006 ER - TY - JOUR AU - Boidot, R. PY - 2012 DA - 2012// TI - Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors JO - Cancer Res VL - 72 UR - https://doi.org/10.1158/0008-5472.CAN-11-2474 DO - 10.1158/0008-5472.CAN-11-2474 ID - Boidot2012 ER - TY - JOUR AU - Doherty, J. R. PY - 2014 DA - 2014// TI - Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis JO - Cancer Res VL - 74 UR - https://doi.org/10.1158/0008-5472.CAN-13-2034 DO - 10.1158/0008-5472.CAN-13-2034 ID - Doherty2014 ER - TY - JOUR AU - Dhup, S. AU - Dadhich, R. K. AU - Porporato, P. E. AU - Sonveaux, P. PY - 2012 DA - 2012// TI - Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis JO - Curr Pharm Des VL - 18 UR - https://doi.org/10.2174/138161212799504902 DO - 10.2174/138161212799504902 ID - Dhup2012 ER - TY - JOUR AU - Hong, C. S. PY - 2016 DA - 2016// TI - MCT1 modulates cancer cell pyruvate export and growth of tumors that co-express MCT1 and MCT4 JO - Cell Rep VL - 14 UR - https://doi.org/10.1016/j.celrep.2016.01.057 DO - 10.1016/j.celrep.2016.01.057 ID - Hong2016 ER - TY - JOUR AU - Floch, R. PY - 2011 DA - 2011// TI - CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1106123108 DO - 10.1073/pnas.1106123108 ID - Floch2011 ER - TY - JOUR AU - Birsoy, K. PY - 2013 DA - 2013// TI - MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors JO - Nat Genet VL - 45 UR - https://doi.org/10.1038/ng.2471 DO - 10.1038/ng.2471 ID - Birsoy2013 ER - TY - JOUR AU - Sayed, S. M. PY - 2014 DA - 2014// TI - Safety and outcome of treatment of metastatic melanoma using 3-bromopyruvate: a concise literature review and case study JO - Chin J Cancer VL - 33 ID - Sayed2014 ER - TY - JOUR AU - Ko, Y. H. PY - 2012 DA - 2012// TI - A translational study “case report” on the small molecule “energy blocker” 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside JO - J Bioenerg Biomembr VL - 44 UR - https://doi.org/10.1007/s10863-012-9417-4 DO - 10.1007/s10863-012-9417-4 ID - Ko2012 ER - TY - JOUR AU - Watanabe, K. PY - 2014 DA - 2014// TI - Integrative ChIP-seq/microarray analysis identifies a CTNNB1 target signature enriched in intestinal stem cells and colon cancer JO - PLoS One VL - 9 UR - https://doi.org/10.1371/journal.pone.0092317 DO - 10.1371/journal.pone.0092317 ID - Watanabe2014 ER - TY - JOUR AU - Huang, S. -. M. A. PY - 2009 DA - 2009// TI - Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling JO - Nature VL - 461 UR - https://doi.org/10.1038/nature08356 DO - 10.1038/nature08356 ID - Huang2009 ER - TY - JOUR AU - Veeman, M. T. AU - Slusarski, D. C. AU - Kaykas, A. AU - Louie, S. H. AU - Moon, R. T. PY - 2003 DA - 2003// TI - Zebrafish prickle, a modulator of noncanonical Wnt/Fz signaling, regulates gastrulation movements JO - Curr Biol VL - 13 UR - https://doi.org/10.1016/S0960-9822(03)00240-9 DO - 10.1016/S0960-9822(03)00240-9 ID - Veeman2003 ER - TY - JOUR AU - Chiche, J. PY - 2012 DA - 2012// TI - In vivo pH in metabolic-defective Ras-transformed fibroblast tumors: key role of the monocarboxylate transporter, MCT4, for inducing an alkaline intracellular pH JO - Int J Cancer VL - 130 UR - https://doi.org/10.1002/ijc.26125 DO - 10.1002/ijc.26125 ID - Chiche2012 ER - TY - JOUR AU - Hoverter, N. P. PY - 2014 DA - 2014// TI - The TCF C-clamp DNA binding domain expands the Wnt transcriptome via alternative target recognition JO - Nucleic Acids Res VL - 42 UR - https://doi.org/10.1093/nar/gku1186 DO - 10.1093/nar/gku1186 ID - Hoverter2014 ER - TY - JOUR AU - Baltazar, F. PY - 2014 DA - 2014// TI - Monocarboxylate transporters as targets and mediators in cancer therapy response JO - Histol Histopathol VL - 29 ID - Baltazar2014 ER - TY - JOUR AU - Morais-Santos, F. PY - 2015 DA - 2015// TI - Targeting lactate transport suppresses in vivo breast tumour growth JO - Oncotarget VL - 6 UR - https://doi.org/10.18632/oncotarget.3910 DO - 10.18632/oncotarget.3910 ID - Morais-Santos2015 ER - TY - JOUR AU - Sonveaux, P. PY - 2008 DA - 2008// TI - Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice JO - J Clin Invest VL - 118 ID - Sonveaux2008 ER - TY - JOUR AU - Baba, M. AU - Inoue, M. AU - Itoh, K. AU - Nishizawa, Y. PY - 2008 DA - 2008// TI - Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism JO - Biochem Biophys Res Commun VL - 374 UR - https://doi.org/10.1016/j.bbrc.2008.06.122 DO - 10.1016/j.bbrc.2008.06.122 ID - Baba2008 ER - TY - JOUR AU - Kirk, P. PY - 2000 DA - 2000// TI - CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression JO - EMBO J VL - 19 UR - https://doi.org/10.1093/emboj/19.15.3896 DO - 10.1093/emboj/19.15.3896 ID - Kirk2000 ER - TY - JOUR AU - Nilsson, H. PY - 2015 DA - 2015// TI - Primary clear cell renal carcinoma cells display minimal mitochondrial respiratory capacity resulting in pronounced sensitivity to glycolytic inhibition by 3-Bromopyruvate JO - Cell Death Dis VL - 6 UR - https://doi.org/10.1038/cddis.2014.545 DO - 10.1038/cddis.2014.545 ID - Nilsson2015 ER - TY - JOUR AU - Parks, S. K. AU - Chiche, J. AU - Pouyssegur, J. PY - 2011 DA - 2011// TI - pH control mechanisms of tumor survival and growth JO - J Cell Physiol VL - 226 UR - https://doi.org/10.1002/jcp.22400 DO - 10.1002/jcp.22400 ID - Parks2011 ER - TY - JOUR AU - Proffitt, K. D. PY - 2013 DA - 2013// TI - Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-12-2258 DO - 10.1158/0008-5472.CAN-12-2258 ID - Proffitt2013 ER - TY - JOUR AU - Kahn, M. PY - 2014 DA - 2014// TI - Can we safely target the WNT pathway? JO - Nat Rev Drug Discov VL - 13 UR - https://doi.org/10.1038/nrd4233 DO - 10.1038/nrd4233 ID - Kahn2014 ER - TY - STD TI - Stamos JL, Weis WI. The β-catenin destruction complex. Cold Spring Harb Perspect Biol. 2013;5. ID - ref43 ER - TY - JOUR AU - Lau, T. PY - 2013 DA - 2013// TI - A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth JO - Cancer Res VL - 73 UR - https://doi.org/10.1158/0008-5472.CAN-12-4562 DO - 10.1158/0008-5472.CAN-12-4562 ID - Lau2013 ER - TY - STD TI - Wu X, Luo F, Li J, Zhong X, Liu K. Tankyrase 1 inhibitior XAV939 increases chemosensitivity in colon cancer cell lines via inhibition of the Wnt signaling pathway. Int J Oncol. 2013;5(1):a007898. ID - ref45 ER - TY - JOUR AU - Rahl, P. B. PY - 2010 DA - 2010// TI - C-Myc regulates transcriptional pause release JO - Cell VL - 141 UR - https://doi.org/10.1016/j.cell.2010.03.030 DO - 10.1016/j.cell.2010.03.030 ID - Rahl2010 ER - TY - JOUR AU - Monici, M. PY - 2003 DA - 2003// TI - Dependence of leukemic cell autofluorescence patterns on the degree of differentiation JO - Photochem Photobiol Sci VL - 2 UR - https://doi.org/10.1039/b306276g DO - 10.1039/b306276g ID - Monici2003 ER -