|
Metabolite
|
% of control serum
|
P value after pFDR correction
|
|---|
|
Glucose
|
42.0
|
5.5E−08
|
|
Lysine
|
47.2
|
2.4E−07
|
|
Lactate
|
50.8
|
3.1E−07
|
|
Alanine
|
52.0
|
5.53E−08
|
|
Pyruvate
|
57.3
|
5.6E−06
|
|
Tyrosine
|
57.7
|
1.07E−06
|
|
Fumarate
|
60.4
|
0.008
|
|
2-Oxoglutarate
|
61.9
|
0.023
|
|
Ornithine
|
66.1
|
0.018
|
|
Acetoacetate
|
842.2
|
4.1E−04
|
|
3-Hydroxybutyrate
|
500.2
|
4.1E−04
|
|
Urea
|
164.8
|
0.004
|
|
Acetone
|
152.8
|
0.017
|
- Values represent the average serum concentration change (as percent change in serum from CR mice relative to control-fed mice) of the identified, statistically significant metabolites (Fig. 4c), based on p values after positive false discovery rate (pFDR) correction <0.05
