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Table 1 Effect of CR on serum metabolites

From: Starving cancer from the outside and inside: separate and combined effects of calorie restriction and autophagy inhibition on Ras-driven tumors

Metabolite

% of control serum

P value after pFDR correction

Glucose

42.0

5.5E−08

Lysine

47.2

2.4E−07

Lactate

50.8

3.1E−07

Alanine

52.0

5.53E−08

Pyruvate

57.3

5.6E−06

Tyrosine

57.7

1.07E−06

Fumarate

60.4

0.008

2-Oxoglutarate

61.9

0.023

Ornithine

66.1

0.018

Acetoacetate

842.2

4.1E−04

3-Hydroxybutyrate

500.2

4.1E−04

Urea

164.8

0.004

Acetone

152.8

0.017

  1. Values represent the average serum concentration change (as percent change in serum from CR mice relative to control-fed mice) of the identified, statistically significant metabolites (Fig. 4c), based on p values after positive false discovery rate (pFDR) correction <0.05