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Fig. 5 | Cancer & Metabolism

Fig. 5

From: Metabolic requirements for cancer cell proliferation

Fig. 5

Metabolic flux alterations predicted to occur in response to inhibition of NADH oxidation in the ETC in simulations of metformin treatment. (a) Schematic indicating absolute and relative flux values in central carbon metabolism for 0, 50, and 100 % inhibition cases; cellular compartmentalization not shown for simplicity. (b) Oxygen consumption, (c) glucose consumption, (d) lactate production, and (e) net IDH fluxes plotted as functions of percent NADH oxidation inhibition

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Cancer & Metabolism

ISSN: 2049-3002