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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells

Fig. 4

a Expected labelling patterns in malonate derived from oxaloacetate by decarboxylation and expected signal patterns in directly observed 13C spectra. b Slices from HSQC spectra for malonate for [1,2-13C]glucose-derived samples with (red) and without (blue) BaP treatment. c Peak patterns observed for malonate in 1H-13C-HSQC spectra, red for [1,2-13C]glucose-labelled cells, blue for [1-13C]glucose-labelled cells. d 13C-NMR spectra for the carboxylic acid region showing the spectrum arising from [1,2-13C]glucose with BaP in blue and the reference spectrum of unlabelled malonate in red. The lack of a centre peak proves that 13COO is always adjacent to a labelled CH2. The asterisk denotes a non-malonate-derived carbon atom

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Cancer & Metabolism

ISSN: 2049-3002