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Table 2 Metabolite levels for the metabolic clusters

From: Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes

  Mc1 (n = 58) Mc2 (n = 58) Mc3 (n = 112) Adjusted p value Significant between
Metabolite name Mean SE Mean SE Mean SE   
Beta-d-glucose 30.0 27.7 71.7 55.2 32.3 16.3 3.62E-09 Mc2 vs rest
Ascorbate 40.0 17.1 28.8 8.6 38.3 13.6 1.02E-05 Mc2 vs rest
Lactate 259.5 73.0 229.4 57.6 303.6 76.7 4.98E-09 Mc3 vs rest
L-tyrosine 407.5 56.5 352.8 82.6 405.9 62.4 1.22E-04 Mc2 vs rest
Glycine 187.0 80.8 152.3 41.9 195.7 68.8 1.04E-04 Mc2 vs Mc3
Myoinositol 163.7 47.0 217.7 53.5 196.1 54.3 9.44E-07 all
Taurine 332.2 122.7 330.2 84.0 369.3 99.3 0.017 Mc1 vs Mc3
Scylloinositol 55.0 16.2 94.7 186.5 62.5 32.1 0.138 NS
Glycerophosphocholine 210.0 91.6 107.9 33.6 151.2 48.4 4.44E-12 all
Phosphocholine 552.0 131.1 216.8 66.8 327.2 69.9 9.59E-33 all
Choline 135.2 44.6 120.3 37.7 132.9 42.2 0.128 NS
Creatine 149.9 64.2 93.2 33.7 136.0 52.1 1.41E-09 Mc2 vs rest
Glutathione 57.5 13.8 50.9 13.9 58.1 14.5 0.011 Mc2 vs Mc3
Glutamine 134.4 41.3 134.3 30.2 145.4 43.6 0.223 NS
Succinate 58.0 15.7 53.6 10.6 62.2 15.7 0.003 Mc2 vs Mc3
Glutamate 237.9 61.3 266.2 63.3 277.5 61.2 1.95E-04 Mc1 vs rest
Acetate 32.7 9.0 48.4 17.2 40.3 13.1 7.89E-08 all
Alanine 82.6 36.6 66.0 24.9 95.1 33.8 6.56E-07 all
  1. The values are calculated by integrated peak areas from normalized spectra to equal total areas. Kruskal-Wallis test was performed to compare metabolite levels between clusters, and p values were adjusted for multiple testing by The Benjamini Hochberg false discovery rate
  2. NS not significant (adjusted p > 0.05)