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Table 2 Metabolite levels for the metabolic clusters

From: Metabolic clusters of breast cancer in relation to gene- and protein expression subtypes

 

Mc1 (n = 58)

Mc2 (n = 58)

Mc3 (n = 112)

Adjusted p value

Significant between

Metabolite name

Mean

SE

Mean

SE

Mean

SE

  

Beta-d-glucose

30.0

27.7

71.7

55.2

32.3

16.3

3.62E-09

Mc2 vs rest

Ascorbate

40.0

17.1

28.8

8.6

38.3

13.6

1.02E-05

Mc2 vs rest

Lactate

259.5

73.0

229.4

57.6

303.6

76.7

4.98E-09

Mc3 vs rest

L-tyrosine

407.5

56.5

352.8

82.6

405.9

62.4

1.22E-04

Mc2 vs rest

Glycine

187.0

80.8

152.3

41.9

195.7

68.8

1.04E-04

Mc2 vs Mc3

Myoinositol

163.7

47.0

217.7

53.5

196.1

54.3

9.44E-07

all

Taurine

332.2

122.7

330.2

84.0

369.3

99.3

0.017

Mc1 vs Mc3

Scylloinositol

55.0

16.2

94.7

186.5

62.5

32.1

0.138

NS

Glycerophosphocholine

210.0

91.6

107.9

33.6

151.2

48.4

4.44E-12

all

Phosphocholine

552.0

131.1

216.8

66.8

327.2

69.9

9.59E-33

all

Choline

135.2

44.6

120.3

37.7

132.9

42.2

0.128

NS

Creatine

149.9

64.2

93.2

33.7

136.0

52.1

1.41E-09

Mc2 vs rest

Glutathione

57.5

13.8

50.9

13.9

58.1

14.5

0.011

Mc2 vs Mc3

Glutamine

134.4

41.3

134.3

30.2

145.4

43.6

0.223

NS

Succinate

58.0

15.7

53.6

10.6

62.2

15.7

0.003

Mc2 vs Mc3

Glutamate

237.9

61.3

266.2

63.3

277.5

61.2

1.95E-04

Mc1 vs rest

Acetate

32.7

9.0

48.4

17.2

40.3

13.1

7.89E-08

all

Alanine

82.6

36.6

66.0

24.9

95.1

33.8

6.56E-07

all

  1. The values are calculated by integrated peak areas from normalized spectra to equal total areas. Kruskal-Wallis test was performed to compare metabolite levels between clusters, and p values were adjusted for multiple testing by The Benjamini Hochberg false discovery rate
  2. NS not significant (adjusted p > 0.05)