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Table 2 Metabolites with statistically significant differences between colorectal cancer tissue and adjacent mucosa

From: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool

Metabolic pathway Metabolite p value Fold difference (CRC/mucosa)
Glycine, serine, and threonine metabolism Isobar: betaine aldehyde, N-methyldiethanolamine 0.015 2.68↑
Purine metabolism, adenine containing Adenylosuccinate 0.03 1.88↑
Leucine, isoleucine, and valine metabolism Isovalerate 0.0073 1.45↑
Short-chain fatty acid Valerate 0.013 1.37↑
Nicotinate and nicotinamide metabolism N1-methyl 2-pyridone-5-carboxamide 0.018 1.29↑
Lysine metabolism 2-aminoadipate 0.043 0.93↓
Sphingolipid metabolism Stearoyl sphingomyelin 0.049 0.9↓
Phenylalanine and tyrosine metabolism 4-hydroxyphenylpyruvate 0.05 0.88↓
Fructose, mannose, and galactose metabolism Sorbitol 0.029 0.87↓
Leucine, isoleucine, and valine metabolism Alpha-hydroxyisovalerate 0.037 0.86↓
Glutathione metabolism Cys-gly, oxidized 0.047 0.84↓
Dipeptide Tryptophylglycine 0.041 0.84↓
Secondary bile acid metabolism Deoxycholate 0.045 0.84↓
7-ketodeoxycholate 0.04 0.81↓
Alanine and aspartate metabolism Asparagine 0.025 0.81↓
Dipeptide Aspartylvaline 0.035 0.81↓
Aspartyltryptophan 0.019 0.76↓
Glycolysis, gluconeogenesis, and pyruvate metabolism Fructose-6-phosphate 0.0082 0.75↓
Glucose-6-phosphate (G6P) 0.0025 0.64↓
  1. ↑ designates metabolites with significantly (p ≤ 0.05) higher expression in CRC when compared with adjacent mucosa (metabolite ratio of ≥1.00) and ↓ designates metabolites with significantly (p ≤ 0.05) higher expression in adjacent mucosa when compared with CRC (metabolite ratio of <1.00)