Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool

Table 2 Metabolites with statistically significant differences between colorectal cancer tissue and adjacent mucosa

Metabolic pathway	Metabolite	p value	Fold difference (CRC/mucosa)
Glycine, serine, and threonine metabolism	Isobar: betaine aldehyde, N-methyldiethanolamine	0.015	2.68↑
Purine metabolism, adenine containing	Adenylosuccinate	0.03	1.88↑
Leucine, isoleucine, and valine metabolism	Isovalerate	0.0073	1.45↑
Short-chain fatty acid	Valerate	0.013	1.37↑
Nicotinate and nicotinamide metabolism	N1-methyl 2-pyridone-5-carboxamide	0.018	1.29↑
Lysine metabolism	2-aminoadipate	0.043	0.93↓
Sphingolipid metabolism	Stearoyl sphingomyelin	0.049	0.9↓
Phenylalanine and tyrosine metabolism	4-hydroxyphenylpyruvate	0.05	0.88↓
Fructose, mannose, and galactose metabolism	Sorbitol	0.029	0.87↓
Leucine, isoleucine, and valine metabolism	Alpha-hydroxyisovalerate	0.037	0.86↓
Glutathione metabolism	Cys-gly, oxidized	0.047	0.84↓
Dipeptide	Tryptophylglycine	0.041	0.84↓
Secondary bile acid metabolism	Deoxycholate	0.045	0.84↓
Secondary bile acid metabolism	7-ketodeoxycholate	0.04	0.81↓
Alanine and aspartate metabolism	Asparagine	0.025	0.81↓
Dipeptide	Aspartylvaline	0.035	0.81↓
Dipeptide	Aspartyltryptophan	0.019	0.76↓
Glycolysis, gluconeogenesis, and pyruvate metabolism	Fructose-6-phosphate	0.0082	0.75↓
Glycolysis, gluconeogenesis, and pyruvate metabolism	Glucose-6-phosphate (G6P)	0.0025	0.64↓

↑ designates metabolites with significantly (p ≤ 0.05) higher expression in CRC when compared with adjacent mucosa (metabolite ratio of ≥1.00) and ↓ designates metabolites with significantly (p ≤ 0.05) higher expression in adjacent mucosa when compared with CRC (metabolite ratio of <1.00)

ISSN: 2049-3002