TY - JOUR AU - Brown, Dustin G. AU - Rao, Sangeeta AU - Weir, Tiffany L. AU - O’Malia, Joanne AU - Bazan, Marlon AU - Brown, Regina J. AU - Ryan, Elizabeth P. PY - 2016 DA - 2016/06/06 TI - Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool JO - Cancer & Metabolism SP - 11 VL - 4 IS - 1 AB - Colorectal cancers (CRC) are associated with perturbations in cellular amino acids, nucleotides, pentose-phosphate pathway carbohydrates, and glycolytic, gluconeogenic, and tricarboxylic acid intermediates. A non-targeted global metabolome approach was utilized for exploring human CRC, adjacent mucosa, and stool. In this pilot study, we identified metabolite profile differences between CRC and adjacent mucosa from patients undergoing colonic resection. Metabolic pathway analyses further revealed relationships between complex networks of metabolites. SN - 2049-3002 UR - https://doi.org/10.1186/s40170-016-0151-y DO - 10.1186/s40170-016-0151-y ID - Brown2016 ER -