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Fig. 4 | Cancer & Metabolism

Fig. 4

From: Molecular characterization of Gleason patterns 3 and 4 prostate cancer using reverse Warburg effect-associated genes

Fig. 4

Protein-protein interactions network generated using STRING. The network is made up of the 17 upregulated genes in GP3 relative to GP4 (FOXO1, GPD2, HK2, MYC, ALDOA, SLC16A4, ATG5, TGFB2, TGFB3, EGLN1, GAPDH, CA9, P4HA1, MXI1, MMP9, and PGM1), plus five enriched genes (ATG16L1, ATG12, AKT1, SIRT1, and SIRT3). The network centers on the primary nodal points: FOXO1, AKT1, MYC, and HIF1A, which show the largest number of reciprocal inhibitory and activating functions with each other as well as with their interacting proteins. Activation (green), inhibition (red), binding (blue), post-translational modification (fuchsia), reaction (black line). Directionality is indicated by the arrow

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