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Fig. 1 | Cancer & Metabolism

Fig. 1

From: Integration of omics: more than the sum of its parts

Fig. 1

The number of perturbations and the number of -omics levels determine the possible read-outs. The number of biological states, or perturbations, that are compared in a multi-omics study define the type of information that can be learned. a Graphical depiction of the relative read-out of a single value from an individual -omics study (here, a metabolite) in biological states A and B. b Relative read-out from an integrated -omics study comparing two biological states A and B (using metabolomics (MxP) and transcription (TxP) in this graphic), where each axis is the relative signal of treatment vs. control for each separate -omics regime. These data can be used to improve understanding of existing networks for the system in these two states; however, it cannot provide information about the general relationships between the molecules measured in the two -omics readouts. c Relative integrated read-out from a multi-state experiment, where E 1 -E i represent the different states (e.g., perturbations or time points). These integrated data can potentially reveal a new network capturing the relationships between the metabolites and transcripts of the integrated -omics readouts

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