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Table 2 Kinetic models. Selected kinetic models of metabolic pathways, focusing on reaction kinetics and parameters for mammalian cells

From: Mathematical models of cancer metabolism

Pathway Tissue Major conclusion Reference
Glycolysis Cancer cells Glycolysis has different control steps depending on cell line [88]
Glycolysis Cancer cells GAPDH is the rate limiting step of glycolysis [89]
Pentose phosphate pathway Hepatocytes G6P dehydrogenase controls the oxidative rate and transketolase the non-oxidative rate [90]
One-carbon metabolism Hepatocytes Mitochondrial formate is the major source of cytosolic one-carbon units in proliferating hepatocytes [91]
H2O2 elimination Endothelial cells GSSG reductase controls the NAPDH dependent H2O2 elimination [92]
Mitochondria Hepatocytes The rate of superoxide generation is a function of the proton electrochemical potential [93]
Central metabolism Cancer cells Repression of transaldolase and succinyl-CoA ligase and the synergistic combination of transaldolase and serine hydromethyltransferase significantly reduce growth rate [94]