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Table 1 Association of metabolism with proliferation and remodelling signatures. The Pearson correlation coefficient between the listed gene signatures (rows) and the gene signatures of cell proliferation and tissue remodelling (columns), as obtained from the analysis of about 4000 samples from five cancer types [3]. The genes on the tissue remodelling and cell proliferation and first two groups of signatures were obtained from gene ontology annotations, and they are reported in ref. [3]. The genes in the remaining metabolic signatures were obtained from the KEGG annotations reported in the Molecular Signatures Database (MSigDB) [16]

From: Mathematical models of cancer metabolism

Signature Tissue remodelling Cell proliferation
G1/S transition −0.07 0.85
DNA replication −0.12 0.87
Telomere organization −0.14 0.75
DNA packaging −0.17 0.81
Chromosome segregation −0.15 0.81
G2/M transition −0.15 0.80
Cell division −0.06 0.87
Cell junction organization 0.66 −0.05
Cell adhesion 0.81 −0.15
Cell migration 0.86 −0.05
Angiogenesis 0.77 −0.04
Cytokine production 0.62 −0.02
Inflammatory response 0.67 −0.07
Response to wounding 0.82 −0.05
Glycolysis 0.08 0.37
Pentose phosphate pathway 0.02 0.37
Oxidative phosphorylation −0.22 0.34
TCA cycle −0.12 0.41
Serine, glycine, 1C metabolism −0.16 0.48
Ribosome −0.13 0.14
Lysosome 0.38 0.09
Fatty acid metabolism −0.02 −0.02