Fig. 3

Predicted metabolic switch. Steady-state metabolic fluxes as a function of the proliferation rate, as predicted from simulations of a genome-scale flux balance model with the macromolecular capacity constraint [45]. The model contains kinetic parameters that are unknown and were sampled from a specified distribution. The line represents the median behaviour and the error bars the 90 % confidence intervals. a) Glucose uptake. b) Lactate excretion. c) Glutamine uptake. d) Pyruvate carboxylase. e) Glycinine cleavage. f) FTHFL. Sum of the reverse FTHFL flux of the cytosolic and mitochondrial enzymes