From: Mitochondria as biosynthetic factories for cancer proliferation
Cancer type (according to primary site) | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Blood, bone, or lymph | Brain | Breast | Colon | Kidney | Liver | Lung | Stomach | Ovarian | Pancreas | Prostate | Skin | |
TCA cycle, anaplerosis, and AcCoA metabolism | ||||||||||||
Pyruvate carboxylase | • | • | • | • | • | • | • | • | ||||
Pyruvate dehydrogenase complex | • | • | • | • | • | • | • | • | ||||
Isocitrate dehydrogenase (activity or mutation) | • | • | • | • | • | • | • | • | • | |||
Succinate dehydrogenase (mutation) | • | |||||||||||
Fumarate hydratase (mutation) | • | |||||||||||
Glutaminase and/or glutamate dehydrogenase | • | • | • | • | • | • | • | • | • | |||
Glutamine synthetase | • | • | • | |||||||||
Amino acid metabolism | ||||||||||||
Pyrroline-5-carboxylate reductase | • | • | • | • | • | • | • | • | • | • | ||
Proline oxidase | • | • | • | • | • | • | • | • | • | • | • | • |
Aspartate transaminase | • | • | • | |||||||||
Alanine transaminase | • | • | • | • | • | • | ||||||
Nucleotide biosynthesis | ||||||||||||
Dihydroorotate dehydrogenase | • | • | • | • | • | • | • | • | ||||
Methylenetetrahydrofolate dehydrogenase | • | • | • | • | • | • | • | • | • | • | • |