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Figure 4 | Cancer & Metabolism

Figure 4

From: Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane

Figure 4

Simulations of periodic intervals of an increased demand for ATP, at the region within 1 μm from the cell membrane, on a 1D cell (Additional file1: Figure S2). (A) Top: periodic ATP demand; middle: ATP level (green line); bottom: mitochondrial ATP production (blue) and glycolytic ATP production (red). (B) Total ATP production rate of the glycolytic pathway (red triangles) and mitochondrial respiration rate (blue circles) at different pulse frequencies, where frequency increment/reduction represent activation/inhibition of membrane demand. While glycolytic production rate is highly dependent on the demand frequency, mitochondrial production rate remains relatively constant, similar to the experimental results shown in Figure 2.

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Cancer & Metabolism

ISSN: 2049-3002