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Figure 3 | Cancer & Metabolism

Figure 3

From: Separation of metabolic supply and demand: aerobic glycolysis as a normal physiological response to fluctuating energetic demands in the membrane

Figure 3

Metabolic profile of adaptation to chronic increase of membrane transporter activity using plasma membrane ATPase 1 (PMA1)-cloned MCF7. The proton production rate (PPR) and oxygen consumption rate (OCR) were measured in the indicated cell lines. (A) Basal, non-glycolytic, PPR, indicating H+ pump activity is significantly higher in the PMA1 clone compared to control cells MCF7 or mock (measured in the absence of glucose). (B) Glycolytic PPR was significantly higher in the PMA1 clone (2.1-fold, compared to control cells MCF7 or mock-transfected cells) but (C) there was no significant change in OCR. The data represent the mean ± standard error from three individual experiments. The two-tailed Student t-test was used to calculate statistical significance: *P <0.05; error bars represent SD (n = 4).

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Cancer & Metabolism

ISSN: 2049-3002