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Figure 4 | Cancer & Metabolism

Figure 4

From: Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

Figure 4

Schematic illustrating 'hard-wired’ interconnections among growth promoting signals, HIF and metabolic/angiogenic pathways. During physiological growth these pathways are tightly regulated (left panel). In oncogenesis, increased growth activates the 'hard-wired’ connections to generate the metabolic and angiogenic characteristics of cancer (upper right panel). Because different oncogenic signals have quantitatively and qualitatively different connections with hypoxia inducible factor (HIF) and metabolic/angiogenic pathways, dysregulated stochastic activation of oncogenic signaling by somatic mutation in cancer has the potential to 'co-select’ grossly disorganized metabolic and angiogenic phenotypes (lower right panel).

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