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Figure 2 | Cancer & Metabolism

Figure 2

From: Hypoxia signaling pathways in cancer metabolism: the importance of co-selecting interconnected physiological pathways

Figure 2

Oncogenic signals act through multiple parallel pathways to activate HIF and its target genes. In addition to regulation by hypoxia, hydroxylation of hypoxia inducible factor (HIF)-α may be influenced by metabolic and redox signals. In cancer, all of these micro-environmental stresses can inhibit hydroxylation leading to accumulation of HIF. Oncogenic signals also impinge on the HIF pathway at many other points, including transcription, translation, post-translational modification and pVHL-mediated degradation of HIF-α polypeptides. In addition, oncogenic signals activate many HIF target genes directly.

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