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Figure 3 | Cancer & Metabolism

Figure 3

From: Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

Figure 3

Histone methylation is transcriptionally promoted after Sdhb knockdown. (A) For topological analysis of metabolism, a human genome-scale metabolic network was used where the gene reaction association was mapped from human to mouse genes. Reporter metabolites, hotspots in metabolism around which significant transcriptional changes occur, are highlighted in red (upregulation) and blue (downregulation) nodes in the network when comparing C1-scr against C1-sh1-Sdhb cells. (B) A subnetwork found to be transcriptionally affected was S-Adenosyl methionine (SAM) metabolism. Both SAM, S-adenosyl homocysteine (SAH) and tetrahydrofolate (THF) were identified as reporter metabolites significantly (p < 0.005) affected by transcriptional upregulation of their neighboring enzymes. (C) A selection of GO terms related to histone methylation found significantly (p < 0.05) enriched by upregulated genes. The bar plot shows the number of upregulated and downregulated genes in each GO term and their individual fold changes in red and blue.

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