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Figure 3 | Cancer & Metabolism

Figure 3

From: Endothelial cell metabolism: parallels and divergences with cancer cell metabolism

Figure 3

Glycolysis compartmentalization for cell motility. (A) Model of lateral inhibition: activation of VEGFR2 in the tip cell by VEGF induces upregulation of Dll4. Activation of Notch on neighboring ECs by Dll4 generates the signaling Notch intracellular domain (NICD), which lowers expression of VEGFR2 and thereby specifies this cell into a stalk cell. Activation of VEGFR upregulates the expression of PFKFB3 and increases glycolysis. Note that glycolytic enzymes and glycolytic ATP production are localized and concentrated in the lamellipodia and filopodia of ECs, where they interact with the actin cytoskeleton. (B) In cancer cells, glycolytic enzymes are also concentrated in invasive invadopodia. (C) Likewise, glycolytic enzymes are present at higher levels in the motile tail of sperm cells or in motile predatory tentacles of the hydra, suggesting that glycolysis mediates rapid movements of these structures.

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