TY - JOUR AU - Shukla, Surendra K. AU - Gebregiworgis, Teklab AU - Purohit, Vinee AU - Chaika, Nina V. AU - Gunda, Venugopal AU - Radhakrishnan, Prakash AU - Mehla, Kamiya AU - Pipinos, Iraklis I. AU - Powers, Robert AU - Yu, Fang AU - Singh, Pankaj K. PY - 2014 DA - 2014/09/01 TI - Metabolic reprogramming induced by ketone bodies diminishes pancreatic cancer cachexia JO - Cancer & Metabolism SP - 18 VL - 2 IS - 1 AB - Aberrant energy metabolism is a hallmark of cancer. To fulfill the increased energy requirements, tumor cells secrete cytokines/factors inducing muscle and fat degradation in cancer patients, a condition known as cancer cachexia. It accounts for nearly 20% of all cancer-related deaths. However, the mechanistic basis of cancer cachexia and therapies targeting cancer cachexia thus far remain elusive. A ketogenic diet, a high-fat and low-carbohydrate diet that elevates circulating levels of ketone bodies (i.e., acetoacetate, β-hydroxybutyrate, and acetone), serves as an alternative energy source. It has also been proposed that a ketogenic diet leads to systemic metabolic changes. Keeping in view the significant role of metabolic alterations in cancer, we hypothesized that a ketogenic diet may diminish glycolytic flux in tumor cells to alleviate cachexia syndrome and, hence, may provide an efficient therapeutic strategy. SN - 2049-3002 UR - https://doi.org/10.1186/2049-3002-2-18 DO - 10.1186/2049-3002-2-18 ID - Shukla2014 ER -