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Figure 2 | Cancer & Metabolism

Figure 2

From: Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?

Figure 2

Piece #2: The BCL-2 family controls BAK/BAX activation and MOMP. Pro-apoptotic BCL-2 family protein activation is triggered by extra- and intra-cellular signaling. De-repressor BH3-only proteins (green) prevent or disrupt inhibition by anti-apoptotic proteins (red). Direct activator BH3-only proteins (yellow) bind BAK and BAX (blue) to induce their homo-oligomerization and MOMP. Details are provided in the text.

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Cancer & Metabolism

ISSN: 2049-3002