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Figure 1 | Cancer & Metabolism

Figure 1

From: Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?

Figure 1

Piece #1: Tumor suppressor and oncogenic pathways converge on the mitochondrial pathway of apoptosis. Oncogenic (e.g., PI3K/AKT, RAS-MAPK, and Myc) and tumor suppressor pathways (e.g., p53, PTEN, and Rb) act at transcriptional and non-transcriptional levels to modulate cellular sensitivity to detect and repair stress, along with regulating the expression and function of downstream apoptotic proteins. Details are provided in the text.

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