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Figure 4 | Cancer & Metabolism

Figure 4

From: SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis

Figure 4

Schema outlining the opposing effects of the kinome and the acetylome on metabolism in response to energy availability. Fed conditions favor oxidative damage due to the induction of pro-metabolism pathways that are induced by insulin and other cytokines that signal a high-energy availability status that would inactivate sirtuins. A fasting state is proposed to activate sirtuins and should induce cellular pathways that conserve or increase cellular efficiency, resulting in energy conservation and preservation of cellular integrity.

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Cancer & Metabolism

ISSN: 2049-3002