Figure 2
From: p53 promotes the expression of gluconeogenesis-related genes and enhances hepatic glucose production
Activation of p53 is predicted to increase the flux through gluconeogenesis. The pathways supplying precursors to gluconeogenesis and the glucogenic pathway are depicted. Red arrows represent the transcriptionally-regulated reactions of gluconeogenesis. Bold arrows represent reactions predicted to carry higher flux in p53-expressing cells according to iMAT. Proteins whose genes are induced by p53 are depicted in purple rectangles. DHAP, dihydroxyacetone phosphate; G3P, glyceraldehyde 3-phosphate, G6P, glucose-6-phosphate, iMAT, integrative metabolic analysis tool; OAA, oxaloacetate; PEP, phosphoenolpyruvate.