PFK-2/FBPase-2 control of glycolysis and gluconeogenic pathways. Overview of glycolysis and gluconeogenesis. Enzymes: phosphofructokinase (PFK-1), fructose 1,6-bisphosphatase (FBPase), 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases (PFK-2/FBPase-2), pyruvate kinase (PK). Fructose 2,6-bisphosphate is an activator of PFK-1 and inhibitor of FBPase. Fructose 1,6-bisphosphate is an activator of PK. The rest of the enzymes and cofactors have been omitted for simplicity.