Figure 6

Comparison of the nanostructure-initiator mass spectrometry (NIMS) tandem mass spectrometry (MS/MS) fragmentation pattern of a 3^′-deoxy-3^′-fluorothymidine-monophosphate (FLT-MP) reference standard with that of putative FLT-MP from tumor tissues. The FLT-MP fragmentation pattern [M-H] 323.05 m/z) acquired in situ from two separate tumor sections (panel A , two spectra overlay) matches that of an FLT-MP reference standard spotted adjacent to the tumor edge on the same NIMS chip (panel B). The reference standard fragmentation spectrum is displayed inverted to enable a more direct comparison of tumor-derived spectra with that of the reference standard.