Table 1 Genes regulated in response to combined silencing of SREBP1 and SREBP2

PTGS2

1.41

1.77

1.40

1.24

49.64

27.66

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

SERPINE1

2.71

2.36

2.48

3.90

7.18

11.42

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

DDIT3

−1.38

−1.25

1.14

1.11

7.34

10.51

DNA-damage-inducible transcript 3

FOSB

−1.12

1.03

1.57

1.59

8.98

9.31

FBJ murine osteosarcoma viral oncogene homolog B

BMP2

1.83

1.68

2.52

2.20

13.38

8.41

bone morphogenetic protein 2

PPP1R15A

−1.06

1.26

1.58

1.56

5.90

7.54

protein phosphatase 1, regulatory (inhibitor) subunit 15A

SGK1

3.05

2.82

3.25

2.47

9.88

7.18

serum/glucocorticoid regulated kinase 1

IL11

1.29

1.68

1.65

2.52

5.43

6.94

interleukin 11

DUSP1

1.03

1.09

1.07

1.29

4.69

6.73

dual specificity phosphatase 1

RCAN1

1.23

1.43

−1.02

1.10

6.34

6.71

regulator of calcineurin 1

E2F7

1.92

1.38

2.62

2.23

6.93

6.49

E2F transcription factor 7

VEGFA

1.89

2.60

1.96

2.75

5.28

6.44

vascular endothelial growth factor A

ITPRIP

1.80

1.65

1.38

1.51

6.38

6.23

inositol 1, 4, 5-triphosphate receptor interacting protein

ATF3

−1.46

−1.97

−1.30

−1.93

8.09

6.23

activating transcription factor 3

TRIB3

1.09

1.08

1.09

−1.09

4.61

6.11

tribbles homolog 3 (Drosophila)

PLEKHF1

1.04

1.39

1.28

1.37

3.67

6.01

pleckstrin homology domain containing, family F (with FYVE domain) member 1

PLAT

2.88

1.97

2.38

1.23

10.41

5.50

plasminogen activator, tissue

RCAN1

1.06

1.12

−1.13

−1.03

5.69

5.34

regulator of calcineurin 1

ASNS

−1.10

−1.15

−1.16

−1.32

4.54

5.30

asparagine synthetase

INHBE

1.05

1.07

−1.03

1.05

3.06

5.09

inhibin, beta E

JUN

1.47

1.38

2.00

2.01

4.23

5.08

jun oncogene

CTH

−1.33

−1.02

−1.29

1.21

3.22

4.91

cystathionase (cystathionine gamma-lyase)

HERPUD1

−1.01

1.16

−1.25

−1.12

3.48

4.79

homocysteine-inducible, endoplasmic reticulum stress-inducible

MTHFD2

1.68

1.43

1.52

1.65

4.22

4.75

methylenetetrahydrofolate dehydrogenase (NADP+dependent) 2

IL6

2.02

2.29

1.40

1.71

6.66

4.63

interleukin 6 (interferon, beta 2)

NDRG1

−1.04

−1.05

1.21

1.03

4.07

4.30

N-myc downstream regulated 1

CREB5

1.40

1.35

1.65

1.45

4.56

4.25

cAMP responsive element binding protein 5

ETS2

−1.18

1.43

1.05

1.20

2.82

4.02

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

ZNF295

1.03

1.28

1.25

1.41

2.70

3.77

zinc finger protein 295

IL1A

1.17

1.53

1.14

−1.03

3.40

3.75

interleukin 1, alpha

GPT2

−1.18

1.24

1.08

1.24

2.29

3.71

glutamic pyruvate transaminase (alanine aminotransferase) 2

SLC3A2

1.53

1.22

1.06

−1.34

4.21

3.69

solute carrier family 3 (activators of dibasic and neutral amino acid transport) member 2

IRAK2

1.74

1.58

1.55

1.38

5.59

3.62

interleukin-1 receptor-associated kinase 2

CEBPG

1.19

1.12

1.24

1.12

3.65

3.46

CCAAT/enhancer binding protein (C/EBP), gamma

MTHFD2

1.46

1.28

1.32

1.46

4.18

3.42

methylenetetrahydrofolate dehydrogenase (NADP+dependent) 2

IER3

1.42

1.20

1.68

1.29

5.55

3.36

immediate early response 3

ETV5

1.56

1.53

1.41

1.60

3.15

3.34

ets variant 5

ITGA2

1.64

1.40

1.80

1.39

4.53

3.32

integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)

GEM

−1.11

−1.31

−1.02

−1.53

4.81

3.29

GTP binding protein overexpressed in skeletal muscle

DNAJB9

−1.19

1.04

−1.36

−1.27

3.73

3.22

DnaJ (Hsp40) homolog, subfamily B, member 9

NOV

1.06

1.37

−1.04

1.11

2.39

3.17

nephroblastoma overexpressed gene

FICD

1.39

1.34

1.21

1.26

2.63

3.16

FIC domain containing

NOG

1.24

−1.00

1.28

1.50

4.02

3.09

noggin

ST3GAL6

1.06

1.42

1.26

1.34

2.95

3.07

ST3 beta-galactoside alpha-2, 3-sialyltransferase 6

NFIL3

1.25

1.13

1.31

1.12

3.56

3.05

nuclear factor, interleukin 3 regulated

IL1B

1.58

1.35

2.01

1.55

7.94

3.00

interleukin 1, beta

GEM

−1.01

−1.00

1.11

−1.03

1.89

2.88

GTP binding protein overexpressed in skeletal muscle

SLC7A1

1.05

1.05

1.09

1.27

2.37

2.87

solute carrier family 7 (cationic amino acid transporter, y+ system), member 1

SGIP1

−1.13

1.04

1.46

1.50

3.23

2.84

SH3-domain GRB2-like (endophilin) interacting protein 1

SRPK2

1.05

1.11

1.02

1.06

2.37

2.83

SFRS protein kinase 2

CEBPB

−1.30

−1.21

1.04

−1.06

3.21

2.79

CCAAT/enhancer binding protein (C/EBP), beta

DUSP10

−1.02

−1.14

1.32

1.13

2.76

2.76

dual specificity phosphatase 10

C9orf150

1.33

1.48

1.09

−1.15

3.85

2.74

chromosome 9 open reading frame 150

SLC3A2

1.23

−1.13

−1.19

−1.28

3.05

2.66

solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2

SLC6A15

1.12

1.20

1.21

1.22

2.99

2.56

solute carrier 6 (neutral amino acid transporter), member 15

NCOA7

−1.07

1.13

−1.07

1.01

2.70

2.53

nuclear receptor coactivator 7

TGIF1

−1.28

−1.04

−1.15

−1.01

2.08

2.51

TGFB-induced factor homeobox 1

RND3

−1.45

1.03

−1.34

−1.17

2.49

2.49

Rho family GTPase 3

CBS

1.11

1.04

1.02

1.03

2.11

2.43

cystathionine-beta-synthase

NFKBIZ

−1.15

−1.07

1.00

1.02

2.01

2.43

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

STX3

−1.43

−1.43

−1.12

−1.08

1.89

2.42

syntaxin 3

SMOX

1.35

1.14

1.24

1.07

2.78

2.34

spermine oxidase

SAMD4A

1.25

−1.18

1.09

1.05

2.03

2.22

sterile alpha motif domain containing 4A

CLCN7

−1.08

1.23

1.06

1.31

1.72

2.21

chloride channel 7

MXD1

1.20

1.14

1.09

−1.02

2.12

2.20

MAX dimerization protein 1

ADAMTS1

−1.32

−1.24

−1.39

1.14

2.51

2.16

ADAM metallopeptidase with thrombospondin type 1 motif, 1

ASNS

−1.06

−1.02

−1.22

−1.09

2.17

2.15

asparagine synthetase

SIAH2

1.16

1.12

1.04

1.20

1.84

2.13

seven in absentia homolog 2 (Drosophila)

SQSTM1

1.20

−1.13

1.12

1.03

2.00

2.13

sequestosome 1

CCNL1

−1.03

1.04

1.16

1.07

1.87

2.12

cyclin L1

SLC38A1

1.27

1.27

1.47

1.20

1.81

2.12

solute carrier family 38, member 1

HMOX1

1.06

−1.26

−1.27

−1.69

2.22

2.11

heme oxygenase (decycling) 1

SYVN1

1.20

1.17

1.20

1.26

2.55

2.08

synovial apoptosis inhibitor 1, synoviolin

CTH

−1.08

−1.07

−1.03

−1.03

1.72

2.07

cystathionase (cystathionine gamma-lyase)

SLC25A25

1.21

1.06

1.19

1.17

2.03

2.01

solute carrier family 25 (mitochrondrial carrier; phosphate carrier), member 25

FZD2

−1.01

−1.16

1.14

1.04

−1.62

−2.08

frizzled homolog 2 (Drosophila)

ADIPOR2

−1.05

−1.18

−1.02

−1.04

−1.93

−2.23

adiponectin receptor 2

ENC1

−1.02

−1.15

1.08

1.21

−2.00

−2.81

ectodermal-neural cortex (with BTB-like domain)

B3GALNT1

−1.40

−1.48

−1.70

−1.43

−3.00

−3.92

beta-1, 3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

PPP1R3C

−1.23

−1.42

−1.26

−1.15

−5.14

−4.31

protein phosphatase 1, regulatory (inhibitor) subunit 3C

MT1F

−10.78

−8.64

−1.37

−1.26

−3.87

−4.34

metallothionein 1F

FADS2

−1.58

−1.55

−2.18

−1.61

−4.42

−4.77

fatty acid desaturase 2

ACLY

−2.36

−2.47

−2.02

−1.95

−4.87

−5.73

ATP citrate lyase

FADS1

−2.02

−2.05

−2.29

−1.58

−5.53

−6.42

fatty acid desaturase 1

FASN

−1.36

−1.23

−2.71

−1.76

−6.32

−6.96

fatty acid synthase

SLC25A1

−1.53

−2.67

−2.42

−2.79

−5.35

−7.44

solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1

LPIN1

−1.96

−1.83

−2.77

−2.24

−6.16

−8.24

lipin 1

INSIG1

−1.76

−1.91

−4.47

−2.98

−9.60

−11.16

insulin induced gene 1

LDLR

1.19

1.20

−2.09

−1.23

−13.16

−11.20

low density lipoprotein receptor

LSS

−1.35

−1.90

−5.08

−3.10

−10.77

−12.52

lanosterol synthase (2, 3-oxidosqualene-lanosterol cyclase)

DHCR7

1.01

−1.25

−4.74

−2.93

−14.01

−15.03

7-dehydrocholesterol reductase

SCD

−1.45

−1.40

−2.35

−1.79

−16.93

−16.08

stearoyl CoA desaturase (delta-9-desaturase)