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Table 1 Genes regulated in response to combined silencing of SREBP1 and SREBP2

From: Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

symbol siBP1 EtOH siBP1 4-OHT siBP2 EtOH siBP2 4-OHT siBP1+2 EtOH siBP1+2 4-OHT genename
PTGS2 1.41 1.77 1.40 1.24 49.64 27.66 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
SERPINE1 2.71 2.36 2.48 3.90 7.18 11.42 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
DDIT3 −1.38 −1.25 1.14 1.11 7.34 10.51 DNA-damage-inducible transcript 3
FOSB −1.12 1.03 1.57 1.59 8.98 9.31 FBJ murine osteosarcoma viral oncogene homolog B
BMP2 1.83 1.68 2.52 2.20 13.38 8.41 bone morphogenetic protein 2
PPP1R15A −1.06 1.26 1.58 1.56 5.90 7.54 protein phosphatase 1, regulatory (inhibitor) subunit 15A
SGK1 3.05 2.82 3.25 2.47 9.88 7.18 serum/glucocorticoid regulated kinase 1
IL11 1.29 1.68 1.65 2.52 5.43 6.94 interleukin 11
DUSP1 1.03 1.09 1.07 1.29 4.69 6.73 dual specificity phosphatase 1
RCAN1 1.23 1.43 −1.02 1.10 6.34 6.71 regulator of calcineurin 1
E2F7 1.92 1.38 2.62 2.23 6.93 6.49 E2F transcription factor 7
VEGFA 1.89 2.60 1.96 2.75 5.28 6.44 vascular endothelial growth factor A
ITPRIP 1.80 1.65 1.38 1.51 6.38 6.23 inositol 1, 4, 5-triphosphate receptor interacting protein
ATF3 −1.46 −1.97 −1.30 −1.93 8.09 6.23 activating transcription factor 3
TRIB3 1.09 1.08 1.09 −1.09 4.61 6.11 tribbles homolog 3 (Drosophila)
PLEKHF1 1.04 1.39 1.28 1.37 3.67 6.01 pleckstrin homology domain containing, family F (with FYVE domain) member 1
PLAT 2.88 1.97 2.38 1.23 10.41 5.50 plasminogen activator, tissue
RCAN1 1.06 1.12 −1.13 −1.03 5.69 5.34 regulator of calcineurin 1
ASNS −1.10 −1.15 −1.16 −1.32 4.54 5.30 asparagine synthetase
INHBE 1.05 1.07 −1.03 1.05 3.06 5.09 inhibin, beta E
JUN 1.47 1.38 2.00 2.01 4.23 5.08 jun oncogene
CTH −1.33 −1.02 −1.29 1.21 3.22 4.91 cystathionase (cystathionine gamma-lyase)
HERPUD1 −1.01 1.16 −1.25 −1.12 3.48 4.79 homocysteine-inducible, endoplasmic reticulum stress-inducible
MTHFD2 1.68 1.43 1.52 1.65 4.22 4.75 methylenetetrahydrofolate dehydrogenase (NADP+dependent) 2
IL6 2.02 2.29 1.40 1.71 6.66 4.63 interleukin 6 (interferon, beta 2)
NDRG1 −1.04 −1.05 1.21 1.03 4.07 4.30 N-myc downstream regulated 1
CREB5 1.40 1.35 1.65 1.45 4.56 4.25 cAMP responsive element binding protein 5
ETS2 −1.18 1.43 1.05 1.20 2.82 4.02 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
ZNF295 1.03 1.28 1.25 1.41 2.70 3.77 zinc finger protein 295
IL1A 1.17 1.53 1.14 −1.03 3.40 3.75 interleukin 1, alpha
GPT2 −1.18 1.24 1.08 1.24 2.29 3.71 glutamic pyruvate transaminase (alanine aminotransferase) 2
SLC3A2 1.53 1.22 1.06 −1.34 4.21 3.69 solute carrier family 3 (activators of dibasic and neutral amino acid transport) member 2
IRAK2 1.74 1.58 1.55 1.38 5.59 3.62 interleukin-1 receptor-associated kinase 2
CEBPG 1.19 1.12 1.24 1.12 3.65 3.46 CCAAT/enhancer binding protein (C/EBP), gamma
MTHFD2 1.46 1.28 1.32 1.46 4.18 3.42 methylenetetrahydrofolate dehydrogenase (NADP+dependent) 2
IER3 1.42 1.20 1.68 1.29 5.55 3.36 immediate early response 3
ETV5 1.56 1.53 1.41 1.60 3.15 3.34 ets variant 5
ITGA2 1.64 1.40 1.80 1.39 4.53 3.32 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
GEM −1.11 −1.31 −1.02 −1.53 4.81 3.29 GTP binding protein overexpressed in skeletal muscle
DNAJB9 −1.19 1.04 −1.36 −1.27 3.73 3.22 DnaJ (Hsp40) homolog, subfamily B, member 9
NOV 1.06 1.37 −1.04 1.11 2.39 3.17 nephroblastoma overexpressed gene
FICD 1.39 1.34 1.21 1.26 2.63 3.16 FIC domain containing
NOG 1.24 −1.00 1.28 1.50 4.02 3.09 noggin
ST3GAL6 1.06 1.42 1.26 1.34 2.95 3.07 ST3 beta-galactoside alpha-2, 3-sialyltransferase 6
NFIL3 1.25 1.13 1.31 1.12 3.56 3.05 nuclear factor, interleukin 3 regulated
IL1B 1.58 1.35 2.01 1.55 7.94 3.00 interleukin 1, beta
GEM −1.01 −1.00 1.11 −1.03 1.89 2.88 GTP binding protein overexpressed in skeletal muscle
SLC7A1 1.05 1.05 1.09 1.27 2.37 2.87 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SGIP1 −1.13 1.04 1.46 1.50 3.23 2.84 SH3-domain GRB2-like (endophilin) interacting protein 1
SRPK2 1.05 1.11 1.02 1.06 2.37 2.83 SFRS protein kinase 2
CEBPB −1.30 −1.21 1.04 −1.06 3.21 2.79 CCAAT/enhancer binding protein (C/EBP), beta
DUSP10 −1.02 −1.14 1.32 1.13 2.76 2.76 dual specificity phosphatase 10
C9orf150 1.33 1.48 1.09 −1.15 3.85 2.74 chromosome 9 open reading frame 150
SLC3A2 1.23 −1.13 −1.19 −1.28 3.05 2.66 solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
SLC6A15 1.12 1.20 1.21 1.22 2.99 2.56 solute carrier 6 (neutral amino acid transporter), member 15
NCOA7 −1.07 1.13 −1.07 1.01 2.70 2.53 nuclear receptor coactivator 7
TGIF1 −1.28 −1.04 −1.15 −1.01 2.08 2.51 TGFB-induced factor homeobox 1
RND3 −1.45 1.03 −1.34 −1.17 2.49 2.49 Rho family GTPase 3
CBS 1.11 1.04 1.02 1.03 2.11 2.43 cystathionine-beta-synthase
NFKBIZ −1.15 −1.07 1.00 1.02 2.01 2.43 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
STX3 −1.43 −1.43 −1.12 −1.08 1.89 2.42 syntaxin 3
SMOX 1.35 1.14 1.24 1.07 2.78 2.34 spermine oxidase
SAMD4A 1.25 −1.18 1.09 1.05 2.03 2.22 sterile alpha motif domain containing 4A
CLCN7 −1.08 1.23 1.06 1.31 1.72 2.21 chloride channel 7
MXD1 1.20 1.14 1.09 −1.02 2.12 2.20 MAX dimerization protein 1
ADAMTS1 −1.32 −1.24 −1.39 1.14 2.51 2.16 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ASNS −1.06 −1.02 −1.22 −1.09 2.17 2.15 asparagine synthetase
SIAH2 1.16 1.12 1.04 1.20 1.84 2.13 seven in absentia homolog 2 (Drosophila)
SQSTM1 1.20 −1.13 1.12 1.03 2.00 2.13 sequestosome 1
CCNL1 −1.03 1.04 1.16 1.07 1.87 2.12 cyclin L1
SLC38A1 1.27 1.27 1.47 1.20 1.81 2.12 solute carrier family 38, member 1
HMOX1 1.06 −1.26 −1.27 −1.69 2.22 2.11 heme oxygenase (decycling) 1
SYVN1 1.20 1.17 1.20 1.26 2.55 2.08 synovial apoptosis inhibitor 1, synoviolin
CTH −1.08 −1.07 −1.03 −1.03 1.72 2.07 cystathionase (cystathionine gamma-lyase)
SLC25A25 1.21 1.06 1.19 1.17 2.03 2.01 solute carrier family 25 (mitochrondrial carrier; phosphate carrier), member 25
FZD2 −1.01 −1.16 1.14 1.04 −1.62 −2.08 frizzled homolog 2 (Drosophila)
ADIPOR2 −1.05 −1.18 −1.02 −1.04 −1.93 −2.23 adiponectin receptor 2
ENC1 −1.02 −1.15 1.08 1.21 −2.00 −2.81 ectodermal-neural cortex (with BTB-like domain)
B3GALNT1 −1.40 −1.48 −1.70 −1.43 −3.00 −3.92 beta-1, 3-N-acetylgalactosaminyltransferase 1 (globoside blood group)
PPP1R3C −1.23 −1.42 −1.26 −1.15 −5.14 −4.31 protein phosphatase 1, regulatory (inhibitor) subunit 3C
MT1F −10.78 −8.64 −1.37 −1.26 −3.87 −4.34 metallothionein 1F
FADS2 −1.58 −1.55 −2.18 −1.61 −4.42 −4.77 fatty acid desaturase 2
ACLY −2.36 −2.47 −2.02 −1.95 −4.87 −5.73 ATP citrate lyase
FADS1 −2.02 −2.05 −2.29 −1.58 −5.53 −6.42 fatty acid desaturase 1
FASN −1.36 −1.23 −2.71 −1.76 −6.32 −6.96 fatty acid synthase
SLC25A1 −1.53 −2.67 −2.42 −2.79 −5.35 −7.44 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
LPIN1 −1.96 −1.83 −2.77 −2.24 −6.16 −8.24 lipin 1
INSIG1 −1.76 −1.91 −4.47 −2.98 −9.60 −11.16 insulin induced gene 1
LDLR 1.19 1.20 −2.09 −1.23 −13.16 −11.20 low density lipoprotein receptor
LSS −1.35 −1.90 −5.08 −3.10 −10.77 −12.52 lanosterol synthase (2, 3-oxidosqualene-lanosterol cyclase)
DHCR7 1.01 −1.25 −4.74 −2.93 −14.01 −15.03 7-dehydrocholesterol reductase
SCD −1.45 −1.40 −2.35 −1.79 −16.93 −16.08 stearoyl CoA desaturase (delta-9-desaturase)
  1. List shows genes identified by microarray analysis as regulated by combined silencing of SREBP1 and SREBP2. Genes were selected to show at least two-fold difference in expression after combined silencing of SREBP1 and SREBP2 compared to control transfected cells or cells transfected with either SREBP1 or SREBP2 targeting siRNAs. Values represent fold-change relative to control-transfected cells treated with ethanol (EtOH) or 4-hydroxytamoxifen (4-OHT), respectively, and are the results of three independent experiments.
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Cancer & Metabolism

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