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Table 3 Effects of FGFR4 deficiency on fatty acid metabolic pathways in breasts and breast tumor

From: Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

Proteins

WT

KO

Tg

KO-Tg

1. Fatty acid metabolism

    

Acot3

1

3.63 (0.23)*

1.41 (0.11)

7.92 (0.44)

Acsl4

1

1.25 (0.17)

26.51 (1.47)

52.33 (3.74)

Acsl5

1

6.52 (0.51)

1.36 (0.14)

5.27 (0.48)

Acsm3

1

16.45 (0.77)

0.87 (0.09)

5.16 (0.42)

Aldh2

1

2.14 (0.13)

2.72 (0.26)

8.03 (0.58)

Acly

1

3.43 (0.37)

1.64 (0.25)

4.32 (0.31)

Acox2

1

0.46 (0.08)

24.76 (0.87)

11.16 (0.58)

HSD17B4

1

1.88 (0.33)

1.62 (0.24)

3.45 (0.41)

2. Fatty acid transport

    

Cpt1b

1

6.92 (0.71)

0.13 (0.02)

0. 72 (0.14)

Cpt2

1

2.82 (0.17)

0.63 (0.09)

3.64 (0.24)

Fabp4

1

1.53 (0.31)

0.05 (0.01)

0.26 (0.02)

Fabp5

1

0.02 (0.003)

0.61 (0.05)

0.04 (0.01)

Slc27a4

1

1.91 (0.35)

0.28 (0.04)

0.64 (0.08)

Slc27a5

1

0.16 (0.04)

2.31 (0.19)

0.74 (0.12)

3. Triacylglycerol Metabolism

    

GyK

1

3.97 (0.28)

10.34 (0.72)

33.59 (0.65)

Gpd2

1

9.92 (0.56)

0.96 (0.22)

4.03 (0.35)

Lipe

1

2.30 (0.15)

0.16 (0.03)

0.43 (0.12)

Lpl

1

0.9 (0.17)

0.12 (0.02)

0.30 (0.03)

  1. *Data are mean (SD): p <0.05 (n = 4 for each group). FGFR, fibroblast growth factor receptor; KO, FGFR4 knockout mice; Tg, MMTV-TGFα transgenic mice; KO-Tg, FGFR4−/−: MMTV-TGFα bigenic mice.