Table 2 Effects of FGFR4 deficiency on adipogenesis, adipose secretory function and metabolic pathways in breasts and breast tumor

1. Adipokines and adipose enzymes:

Adiponectin

1

1.64 (0.23)*

0.01 (0.002)

0.11 (0.02)

Adipsin

1

3.32 (0.17)

0.12 (0.03)

0.43 (0.06)

Leptin

1

0.55 (0.04)

0.003 (0.0001)

0.05 (0.004)

Lipoprotein lipase

1

0.92 (0.17)

0.08 (0.02)

0.25 (0.06)

Hormone sensitive lipase

1

2.02 (0.31)

0.11 (0.02)

0.31 (0.03)

2. PPAR gamma targets:

Fabp4

1

1.62 (0.26)

0.04 (0.01)

0.15 (0.03)

FASN

1

1.01 (0.23)

0.14 (0.03)

0.35 (0.04)

IRS2

1

0.12 (0.03)

1.84 (0.35)

0.27 (0.08)

Glut4

1

0.66 (0.12)

0.05 (0.003)

0.18 (0.04)

SREBP1

1

0.27 (0.06)

1.97 (0.29)

0.33 (0.04)

3. Adipogenesis regulation:

(1) Pro-adipogenesis

Cyclin D1

1

0.46 (0.10)

6.61 (0.29)

3.42 (0.18)

Cdk4

1

0.43 (0.08)

5.14 (0.37)

2.23 (0.19)

Cebpd

1

0.24 (0.05)

7.26 (0.48)

2.46 (0.15)

E2F1

1

0.23 (0.03)

2.16 (0.36)

0.71 (0.11)

Jun

1

0.56 (0.08)

2.93 (0.26)

1.52 (0.30)

Sfrp5

1

0.55 (0.10)

0.01 (0.002)

0.04 (0.005)

Src

1

0.19 (0.03)

4.72 (0.51)

2.31 (0.38)

Wnt5b

1

0.35 (0.06)

3.01 (0.23)

1.37 (0.29)

(2) Anti-adipogenesis

Cdkn1a (p21)

1

1.65 (0.18)

2.44 (0.14)

3.71 (0.26)

Dlk1

1

0.31 (0.04)

1.03 (0.13)

0.12 (0.03)

Klf2

1

0.007 (0.001)

1.23 (0.16)

0.004 (0.0005)

(3) Others

Ppara

1

7.33 (0.47)

0.31 (0.05)

1.36 (0.17)

Ucp1

1

177.1 (1.57)

0.12 (0.02)

9.94 (1.03)