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Table 1 Effects of FGFR4 deficiency on the pathological development of mammary tumors*

From: Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations

Age (months)

Genotype

UDH

hUDH

DCIS

LCIS

Undiff STS

IDC

ILC

6

KO- Tg

57

20

10

13

0

0

0

6

Tg

14

26

23

28

2

2

5

8

KO-Tg

11

27

16

21

13

5

7

8

Tg

6

10

8

11

31

15

19

  1. *Tissue sections from 24 mice each for the FGFR4−/−: MMTV-TGFα bigenic (KO-Tg) and MMTV-TGFα transgenic (Tg) mouse groups at 6 and 8 months were examined for the anatomopathological grades. The predominant pathological category for each section was recorded and the percentage score of each pathological category in total sections analyzed was reported. Three sections for each sample were analyzed. UDH, usual duct hyperplasia; DCIS, ductal carcinomas in situ; LCIS, lobular carcinomas in situ; hUDH, high-grade UDH; IDC, invasive ductal carcinoma; ILC, invasive lobular carcinoma; Undiff STS, undifferentiated solid tumor sheet.
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Cancer & Metabolism

ISSN: 2049-3002