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Table 1 Correlation of exchange fluxes with proliferation rate and protein synthesis rate

From: The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

  Flux per cell versus proliferation rate Flux per cell versus protein synthesis rate Flux per cell volume versus proliferation rate
PCC P PCC P PCC P
  Protein synthesis 0.09 0.250214 1.00 0.000000 0.55 0.000004
Essential amino acids Isoleucine 0.05 0.349331 0.96 0.000000 0.48 0.000082
Leucine 0.08 0.281351 0.98 0.000000 0.54 0.000008
Lysine 0.16 0.108393 0.95 0.000000 0.56 0.000003
Methionine 0.20 0.065968 0.92 0.000000 0.65 0.000000
Phenylalanine 0.12 0.184280 0.97 0.000000 0.59 0.000001
Threonine −0.01 0.466997 0.92 0.000000 0.42 0.000519
Tryptophan 0.01 0.459913 0.83 0.000000 0.37 0.002299
Valine 0.06 0.333105 0.97 0.000000 0.49 0.000068
Non-essential amino acids Alanine 0.38 0.000912 −0.55 0.000040 0.11 0.200642
Arginine 0.10 0.230809 0.45 0.001921 0.39 0.001534
Asparagine 0.15 0.134489 0.51 0.000448 0.43 0.000407
Aspartate 0.04 0.373865 0.18 0.081690 0.14 0.151826
Glutamine −0.23 0.032499 0.78 0.000000 0.13 0.156961
Glutamate 0.26 0.018120 −0.59 0.000080 0.14 0.137636
Glycine 0.51 0.000007 −0.12 0.179629 0.47 0.000066
Proline 0.21 0.047898 −0.30 0.014511 0.03 0.398548
Serine −0.10 0.226831 0.83 0.000000 0.29 0.012954
Tyrosine 0.07 0.282791 0.96 0.000000 0.52 0.000014
Other Glucose −0.17 0.092456 0.80 0.000000 0.21 0.058257
Lactate 0.22 0.043187 −0.76 0.000000 −0.13 0.157716
PPPox 0.34 0.004365 0.66 0.000000 1.00 0.000000
PSAT −0.16 0.104559 0.73 0.000000 0.24 0.033800
PDH 0.48 0.000078 0.29 0.018433 0.72 0.000000
PC 0.02 0.445333 0.52 0.000207 0.35 0.003715
Glutamate →α-KG 0.05 0.358935 0.80 0.000000 0.64 0.000000
ATP synthase 0.00 0.491256 0.94 0.000000 0.52 0.000014
  1. Correlations between the exchange fluxes of amino acids, lactate and glucose and the predicted flux of selected reactions, with either the protein synthesis rate per cell, the proliferation rate, or the proliferation rate after normalizing by cell volume. PCC, Pearson correlation coefficient; P, associated statistical significance; PPPox, oxidative branch of the pentose phosphate pathway; PSAT, phosphoserine transaminase PC, pyruvate carboxylase; α-KG, α-ketoglutarate. Values in bold indicate significance below P <0.05.