Figure 5
From: The metabolic demands of cancer cells are coupled to their size and protein synthesis rates
Gene expression signatures of small/large cells. (a) Gene expression profile of genes with expression that increased (bottom) or decreased (top) with increasing cell volumes (left to right) across the NCI60 cell lines. (b) Gene ontology (GO) terms enriched in genes with expression that decreased from small to large cell lines, quantified by the enrichment significance (y-axis). (c) GO terms enriched in genes with expression that increased from small to large cell lines. (d) Gene expression profiles of the same genes in the cell line A549 before and after treatment with transforming growth factor (TGF)β. (e) Protein expression of vimentin and E-cadherin across the NCI60 cell lines in relation to the cell volume (increases left to right) and the proliferation rate.