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Figure 2 | Cancer & Metabolism

Figure 2

From: The metabolic demands of cancer cells are coupled to their size and protein synthesis rates

Figure 2

Correlation between biomass components and doubling time or cell size. (a) Culture image of the relatively smaller colon cancer cell line HCT-116. (b) Culture image of the relatively larger renal cancer cell line A498. (c) The cell volume scales in proportion with the doubling time. The diamond and circle represent the HCT-116 and A498 cell lines, respectively. (d- f) The protein content, DNA content and protein synthesis rate scale in proportion to the cell volume. The blue dashed-dotted line in panel (e) represents the DNA content associated with the diploid genome of a normal cell. All other lines represent linear fits to the data points.

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