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Table 1 Functional annotation clustering of genes associated with Ets-1 overexpression

From: Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers

Annotation cluster

Index

Term

P

Fold enrichment

1

INTERPRO

IPR010257:Fatty acid desaturase, type 1, N-terminal

0.00

15.75

GOTERM_MF_ALL

GO:0016717~Oxidoreductase activity (O or H2O as acceptor)

0.00

13.63

INTERPRO

IPR005804:Fatty acid desaturase, type 1

0.00

13.13

2

PANTHER_FAMILY

PTHR19353:Fatty acid desaturase 2

0.001

20.40

INTERPRO

IPR012171:Fatty acid/sphingolipid desaturase

0.001

19.69

PIR_SUPERFAMILY

PIRSF015921:Fatty acid desaturase/sphingolipid desaturase

0.001

19.22

GOTERM_BP_ALL

GO:0006636~Unsaturated fatty acid biosynthetic process

0.001

14.89

GOTERM_BP_ALL

GO:0033559~Unsaturated fatty acid metabolic process

0.001

14.89

3

KEGG_REACTION

R05053:D-aspartate + D-4-hydroxy-2-oxoglutarate <=> Oxaloacetate + L-erythro-4-hydroxyglutamate

0.001

2.78

KEGG_COMPOUND

C05947:L-erythro-4-hydroxyglutamate

0.001

2.76

KEGG_COMPOUND

C05946:D-4-hydroxy-2-oxoglutarate

0.001

2.76

KEGG_COMPOUND

C00036:Oxaloacetate

0.001

2.76

KEGG_COMPOUND

C00402:D-aspartate

0.001

2.76

4

GOTERM_MF_ALL

GO:0047115~trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity

0.001

20.44

EC_NUMBER

1.1.1.213

0.001

16.92

EC_NUMBER

14.3.1.20

0.001

16.92

5

PIR_SUPERFAMILY

PIRSF001191:Matrix metalloproteinase, stromelysin type

0.01

5.34

INTERPRO

IPR002477:Peptidoglycan binding-like

0.02

4.92

PANTHER_FAMILY

PTHR10201:Matrix metalloproteinase

0.02

4.43

INTERPRO

IPR000585:Hemopexin

0.03

4.10

INTERPRO

IPR006026:Peptidase, metallopeptidases

0.04

3.79

GOTERM_BP_ALL

GO:0000270~Peptidoglycan metabolic process

0.05

3.54

6

INTERPRO

IPR001314:Peptidase S1A, chymotrypsin

0.02

2.28

INTERPRO

IPR001254:Peptidase S1 and S6, chymotrypsin/Hap

0.04

2.10

PANTHER_FAMILY

PTHR19355:Serine protease-related

0.04

2.10

7

INTERPRO

IPR001039:MHC class I, alpha chain, alpha1 and alpha 2

0.02

4.69

PANTHER_FAMILY

PTHR16675:MHC class 1-related

0.03

4.08

INTERPRO

IPR011161:MHC classi-like antigen recognition

0.04

9.94

GOTERM_CC_ALL

GO:0042612~MHC class I protein complex

0.04

3.91

8

INTERPRO

IPR010579:MHC class I, alpha chain, C-terminal

0.01

14.77

PFAM

PF06623:MHC_I_C

0.01

14.63

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Cancer & Metabolism

ISSN: 2049-3002