Skip to main content

Table 1 Functional annotation clustering of genes associated with Ets-1 overexpression

From: Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers

Annotation cluster Index Term P Fold enrichment
1 INTERPRO IPR010257:Fatty acid desaturase, type 1, N-terminal 0.00 15.75
GOTERM_MF_ALL GO:0016717~Oxidoreductase activity (O or H2O as acceptor) 0.00 13.63
INTERPRO IPR005804:Fatty acid desaturase, type 1 0.00 13.13
2 PANTHER_FAMILY PTHR19353:Fatty acid desaturase 2 0.001 20.40
INTERPRO IPR012171:Fatty acid/sphingolipid desaturase 0.001 19.69
PIR_SUPERFAMILY PIRSF015921:Fatty acid desaturase/sphingolipid desaturase 0.001 19.22
GOTERM_BP_ALL GO:0006636~Unsaturated fatty acid biosynthetic process 0.001 14.89
GOTERM_BP_ALL GO:0033559~Unsaturated fatty acid metabolic process 0.001 14.89
3 KEGG_REACTION R05053:D-aspartate + D-4-hydroxy-2-oxoglutarate <=> Oxaloacetate + L-erythro-4-hydroxyglutamate 0.001 2.78
KEGG_COMPOUND C05947:L-erythro-4-hydroxyglutamate 0.001 2.76
KEGG_COMPOUND C05946:D-4-hydroxy-2-oxoglutarate 0.001 2.76
KEGG_COMPOUND C00036:Oxaloacetate 0.001 2.76
KEGG_COMPOUND C00402:D-aspartate 0.001 2.76
4 GOTERM_MF_ALL GO:0047115~trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity 0.001 20.44
EC_NUMBER 1.1.1.213 0.001 16.92
EC_NUMBER 14.3.1.20 0.001 16.92
5 PIR_SUPERFAMILY PIRSF001191:Matrix metalloproteinase, stromelysin type 0.01 5.34
INTERPRO IPR002477:Peptidoglycan binding-like 0.02 4.92
PANTHER_FAMILY PTHR10201:Matrix metalloproteinase 0.02 4.43
INTERPRO IPR000585:Hemopexin 0.03 4.10
INTERPRO IPR006026:Peptidase, metallopeptidases 0.04 3.79
GOTERM_BP_ALL GO:0000270~Peptidoglycan metabolic process 0.05 3.54
6 INTERPRO IPR001314:Peptidase S1A, chymotrypsin 0.02 2.28
INTERPRO IPR001254:Peptidase S1 and S6, chymotrypsin/Hap 0.04 2.10
PANTHER_FAMILY PTHR19355:Serine protease-related 0.04 2.10
7 INTERPRO IPR001039:MHC class I, alpha chain, alpha1 and alpha 2 0.02 4.69
PANTHER_FAMILY PTHR16675:MHC class 1-related 0.03 4.08
INTERPRO IPR011161:MHC classi-like antigen recognition 0.04 9.94
GOTERM_CC_ALL GO:0042612~MHC class I protein complex 0.04 3.91
8 INTERPRO IPR010579:MHC class I, alpha chain, C-terminal 0.01 14.77
PFAM PF06623:MHC_I_C 0.01 14.63