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  1. Review

    Mathematical models of cancer metabolism

    Metabolism is essential for life, and its alteration is implicated in multiple human diseases. The transformation from a normal to a cancerous cell requires metabolic changes to fuel the high metabolic demands...

    Elke Katrin Markert and Alexei Vazquez

    Cancer & Metabolism 2015 3:14

    Published on: 22 December 2015

  2. Research

    Targeting mitochondrial complex I using BAY 87-2243 reduces melanoma tumor growth

    Numerous studies have demonstrated that functional mitochondria are required for tumorigenesis, suggesting that mitochondrial oxidative phosphorylation (OXPHOS) might be a potential target for cancer therapy. ...

    Laura Schöckel, Andrea Glasauer, Farhan Basit, Katharina Bitschar, Hoa Truong, Gerrit Erdmann, Carolyn Algire, Andrea Hägebarth, Peter HGM Willems, Charlotte Kopitz, Werner JH Koopman and Mélanie Héroult

    Cancer & Metabolism 2015 3:11

    Published on: 20 October 2015

  3. Research

    Targeting glutamine metabolism sensitizes pancreatic cancer to PARP-driven metabolic catastrophe induced by ß-lapachone

    Pancreatic ductal adenocarcinomas (PDA) activate a glutamine-dependent pathway of cytosolic nicotinamide adenine dinucleotide phosphate (NADPH) production to maintain redox homeostasis and support proliferatio...

    Gaurab Chakrabarti, Zachary R. Moore, Xiuquan Luo, Mariya Ilcheva, Aktar Ali, Mahesh Padanad, Yunyun Zhou, Yang Xie, Sandeep Burma, Pier P. Scaglioni, Lewis C. Cantley, Ralph J. DeBerardinis, Alec C. Kimmelman, Costas A. Lyssiotis and David A. Boothman

    Cancer & Metabolism 2015 3:12

    Published on: 12 October 2015

  4. Research

    The rate of glycolysis quantitatively mediates specific histone acetylation sites

    Glucose metabolism links metabolic status to protein acetylation. However, it remains poorly understood to what extent do features of glucose metabolism contribute to protein acetylation and whether the proces...

    Ahmad A. Cluntun, He Huang, Lunzhi Dai, Xiaojing Liu, Yingming Zhao and Jason W. Locasale

    Cancer & Metabolism 2015 3:10

    Published on: 23 September 2015

  5. Research

    Knockout of Vdac1 activates hypoxia-inducible factor through reactive oxygen species generation and induces tumor growth by promoting metabolic reprogramming and inflammation

    Mitochondria are more than just the powerhouse of cells; they dictate if a cell dies or survives. Mitochondria are dynamic organelles that constantly undergo fusion and fission in response to environmental con...

    M. Christiane Brahimi-Horn, Sandy Giuliano, Estelle Saland, Sandra Lacas-Gervais, Tatiana Sheiko, Joffrey Pelletier, Isabelle Bourget, Frédéric Bost, Chloé Féral, Etienne Boulter, Michel Tauc, Mircea Ivan, Barbara Garmy-Susini, Alexandra Popa, Bernard Mari, Jean-Emmanuel Sarry…

    Cancer & Metabolism 2015 3:8

    Published on: 26 August 2015

  6. Research

    Metabolic plasticity maintains proliferation in pyruvate dehydrogenase deficient cells

    Pyruvate dehydrogenase (PDH) occupies a central node of intermediary metabolism, converting pyruvate to acetyl-CoA, thus committing carbon derived from glucose to an aerobic fate rather than an anaerobic one. ...

    Kartik N. Rajagopalan, Robert A. Egnatchik, Maria A. Calvaruso, Ajla T. Wasti, Mahesh S. Padanad, Lindsey K. Boroughs, Bookyung Ko, Christopher T. Hensley, Melih Acar, Zeping Hu, Lei Jiang, Juan M. Pascual, Pier Paolo Scaglioni and Ralph J. DeBerardinis

    Cancer & Metabolism 2015 3:7

    Published on: 29 June 2015

  7. Research

    Quantification of folate metabolism using transient metabolic flux analysis

    Systematic quantitative methodologies are needed to understand the heterogeneity of cell metabolism across cell types in normal physiology, disease, and treatment. Metabolic flux analysis (MFA) can be used to ...

    Philip M Tedeschi, Nadine Johnson-Farley, Hongxia Lin, Laura M Shelton, Takushi Ooga, Gillian Mackay, Niels Van Den Broek, Joseph R Bertino and Alexei Vazquez

    Cancer & Metabolism 2015 3:6

    Published on: 28 May 2015

  8. Research

    An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation

    The gene encoding the serine biosynthesis pathway enzyme PHGDH is located in a region of focal genomic copy number gain in human cancers. Cells with PHGDH amplification are dependent on enzyme expression for prol...

    Katherine R Mattaini, Edward J Brignole, Mitali Kini, Shawn M Davidson, Brian P Fiske, Catherine L Drennan and Matthew G Vander Heiden

    Cancer & Metabolism 2015 3:5

    Published on: 29 April 2015

  9. Review

    Mitophagy and cancer

    Mitophagy is a selective form of macro-autophagy in which mitochondria are selectively targeted for degradation in autophagolysosomes. Mitophagy can have the beneficial effect of eliminating old and/or damaged...

    Aparajita H Chourasia, Michelle L Boland and Kay F Macleod

    Cancer & Metabolism 2015 3:4

    Published on: 26 March 2015

  10. Case report

    Treatment of glioma patients with ketogenic diets: report of two cases treated with an IRB-approved energy-restricted ketogenic diet protocol and review of the literature

    Based on the hypothesis that cancer cells may not be able to metabolize ketones as efficiently as normal brain cells, the ketogenic diet (KD) has been proposed as a complementary or alternative therapy for tre...

    Kenneth Schwartz, Howard T Chang, Michele Nikolai, Joseph Pernicone, Sherman Rhee, Karl Olson, Peter C Kurniali, Norman G Hord and Mary Noel

    Cancer & Metabolism 2015 3:3

    Published on: 25 March 2015

  11. Research

    Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302

    Hypoxic niches in solid tumors harbor therapy-resistant cells. Hypoxia-activated prodrugs (HAPs) have been designed to overcome this resistance and, to date, have begun to show clinical efficacy. However, clin...

    Jonathan W Wojtkowiak, Heather C Cornnell, Shingo Matsumoto, Keita Saito, Yoichi Takakusagi, Prasanta Dutta, Munju Kim, Xiaomeng Zhang, Rafael Leos, Kate M Bailey, Gary Martinez, Mark C Lloyd, Craig Weber, James B Mitchell, Ronald M Lynch, Amanda F Baker…

    Cancer & Metabolism 2015 3:2

    Published on: 29 January 2015

  12. Review

    Mitochondria as biosynthetic factories for cancer proliferation

    Unchecked growth and proliferation is a hallmark of cancer, and numerous oncogenic mutations reprogram cellular metabolism to fuel these processes. As a central metabolic organelle, mitochondria execute critic...

    Christopher S Ahn and Christian M Metallo

    Cancer & Metabolism 2015 3:1

    Published on: 25 January 2015

  13. Research

    Succinate dehydrogenase inhibition leads to epithelial-mesenchymal transition and reprogrammed carbon metabolism

    Succinate dehydrogenase (SDH) is a mitochondrial metabolic enzyme complex involved in both the electron transport chain and the citric acid cycle. SDH mutations resulting in enzymatic dysfunction have been fou...

    Paul-Joseph P Aspuria, Sophia Y Lunt, Leif Väremo, Laurent Vergnes, Maricel Gozo, Jessica A Beach, Brenda Salumbides, Karen Reue, W Ruprecht Wiedemeyer, Jens Nielsen, Beth Y Karlan and Sandra Orsulic

    Cancer & Metabolism 2014 2:21

    Published on: 15 December 2014

  14. Meeting report

    The 2014 Beatson International Cancer Conference: Powering the Cancer Machine

    Here, we present a report of the 2014 annual Beatson International Cancer Conference, Glasgow, July 6–9, 2014. The theme was “Powering the Cancer Machine”, focusing on oncogenic signals that regulate metabolic re...

    Jurre J Kamphorst and Daniel J Murphy

    Cancer & Metabolism 2014 2:25

    Published on: 28 November 2014

    The Erratum to this article has been published in Cancer & Metabolism 2014 2:127

  15. Review

    Mitochondrial reactive oxygen species and cancer

    Mitochondria produce reactive oxygen species (mROS) as a natural by-product of electron transport chain activity. While initial studies focused on the damaging effects of reactive oxygen species, a recent para...

    Lucas B Sullivan and Navdeep S Chandel

    Cancer & Metabolism 2014 2:17

    Published on: 28 November 2014

  16. Research

    Metabolic and transcriptional profiling reveals pyruvate dehydrogenase kinase 4 as a mediator of epithelial-mesenchymal transition and drug resistance in tumor cells

    Accumulating preclinical and clinical evidence implicates epithelial-mesenchymal transition (EMT) in acquired resistance to anticancer drugs; however, mechanisms by which the mesenchymal state determines drug ...

    Yuting Sun, Anneleen Daemen, Georgia Hatzivassiliou, David Arnott, Catherine Wilson, Guanglei Zhuang, Min Gao, Peter Liu, Aaron Boudreau, Leisa Johnson and Jeff Settleman

    Cancer & Metabolism 2014 2:20

    Published on: 3 November 2014

  17. Review

    SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis

    It is a well-established scientific observation that mammalian cells contain fidelity proteins that appear to protect against and adapt to various forms of endogenous and exogenous cellular conditions. Loss of...

    Yueming Zhu, Yufan Yan, Daniel R Principe, Xianghui Zou, Athanassios Vassilopoulos and David Gius

    Cancer & Metabolism 2014 2:15

    Published on: 20 October 2014

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