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Table 3 Additive interaction between metformin and statins in cumulative years based on Model 2

From: Statin use as a moderator on the association between metformin and breast cancer risk in women with type 2 diabetes mellitus

Reference level of metformin (years)

Reference level of statins (years)

increment in metformin (years)

increment in statins (years)

RERI

RERI

95% CI

1

1

1

1

0.291

0.221, 0.361

3

1

1

2

0.445

0.361, 0.529

5

1

1

3

0.516

0.430, 0.601

1

3

2

1

0.435

0.349, 0.521

3

3

2

2

0.661

0.572, 0.751

5

3

2

3

0.765

0.686, 0.843

1

5

3

1

0.497

0.408, 0.586

3

5

3

2

0.754

0.671, 0.837

5

5

3

3

0.870

0.810, 0.930

  1. RERI: relative excess risk due to interaction; that measures additive interaction between continuous risk factors depending both on their background (reference level) and on the “elevated” levels of exposure (increment in years)
  2. The estimate of the multiplicative interaction between metformin and statins was 0.97 [0.95, 0.99] in model 2, that could be found in Table S1
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Cancer & Metabolism

ISSN: 2049-3002