Fig. 3

Metabolite levels in different path_MMR gene cohorts mmol/l (A–H). ANCOVA (A–H) test, incorporating covariates age, sex, and BMI, was used to test the difference between the MLH1 cohort and other path_MMR cohorts, * = corrected p value < 0.05, ** = corrected p value < 0.01. Test and values for all 65 key metabolites comparisons are shown in Supplementary Table S3.