Table 1 Regulation of fatty acid metabolism-related gene expression in hepatocellular carcinoma (HCC) cells under hypoxic conditions
gene | Function in FA metabolism | HepG2 | Hep3B | ||
|---|---|---|---|---|---|
mRNA expression in Hypoxia | Regulation factor | mRNA expression in Hypoxia | Regulation factor | ||
ACSL1 | FAO | down | HIF-1 | down | HIF-1 |
CPT1A | down | HIF-1 | down | HIF-1 | |
ACADM | down | HIF-1 | down | HIF-1 | |
ACADL | down | HIF-1 | down | HIF-1 | |
CD36 | uptake of FA | down | HIF-1 | down | HIF-1 |
AGPAT | Lipid droplets | up | HIF-1 | up | HIF-1 |
DGAT | up | HIF-1 | up | HIF-1 | |