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Fig. 5 | Cancer & Metabolism

Fig. 5

From: ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors

Fig. 5

Combined treatment with KU55933 and crizotinib in H993 cells. A Levels of p-ATM, ATM, PGC-1α, p-p53.Ser15, p53, PARP and cleaved PARP, BIM, and cyclin D1 in H1993 treated with KU55933 (10- nM and 100-nM), crizotinib (0.5 μM and 1 μM), and their combination for 48 h. B Cell viability assay performed in H1993 cells exposed to KU55933 (100-nM), crizotinib (0.5 μM–1 μM), and their combination. Tubulin serves as equal loading control. Symbol * indicates a p-value < 0.05. Symbol *** indicates a p-value < 0.001

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Cancer & Metabolism

ISSN: 2049-3002