Fig. 4

Combined treatment with KU55933 and WZ4002 in H1975 cells. A Levels of p-ATM, ATM, p-EGFR, PGC-1α, p-p53, p53, PARP and cleaved PARP, BIM, cleaved-lamin A/C, and cyclin D1 in H1975 treated with KU55933 (10-nM and 100-nM), WZ4002 (0.5 μM and 1 μM), and their combination for 48 h. B Cell viability assay performed in H1975 cells exposed to increasing concentration of KU55933 (0.01–5 μM) or WZ4002 (0.01–5 μM) alone and to combination treatment with a fixed concentration of KU55933 (10-nM and 100-nM) plus increasing doses of WZ4002 (0.01–5 μM). Tubulin serves as equal loading control