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Fig. 3 | Cancer & Metabolism

Fig. 3

From: ATM inhibition blocks glucose metabolism and amplifies the sensitivity of resistant lung cancer cell lines to oncogene driver inhibitors

Fig. 3

Effects of ATM silencing in oncogene-driven H1993 and H1975 cells. A Levels of HKII, phospho-PKM2Tyr105, PKM2, phospho-PDHSer293, PDH, cyclin D1, and BIM in H1993 and H1975 cells transfected with ATM-targeted small interfering RNA or siRNA control and exposed to crizotinib or WZ4002 for 48 h. B Levels of OXPHOS in H1993 and H1975 cells transfected with ATM-targeted small interfering RNA or siRNA control and exposed to crizotinib or WZ4002 for 48 h. GAPDH and actin serve as equal loading controls

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Cancer & Metabolism

ISSN: 2049-3002