Fig. 1

Effects of ATM inhibition on glycolysis and OXPHOS in oncogene-driven NSCLC H1993 and H1975 cells. A Baseline levels of ATM protein in both cell lines. B Inhibition of ATM phosphorylation after 48-h exposure to 10-nM and 100-nM of KU55933. C Levels of HKII, phospho-PKM2^Tyr105, phospho-PKM2^Ser37, PKM2, LDH-A, phospho-PDH^Ser293, and PDH in basal conditions and after 48-h exposure to 10-nM and 100-nM of KU55933. D Levels of OXPHOS in basal conditions and after 48-h exposure to 10-nM and 100-nM of KU55933. Vinculin, GAPDH, and tubulin serve as equal loading controls