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Fig. 3 | Cancer & Metabolism

Fig. 3

From: Restoring gluconeogenesis by TEF inhibited proliferation and promoted apoptosis and immune surveillance in kidney renal clear cell carcinoma

Fig. 3

Mir-4477b was predicted to suppress gluconeogenesis by targeting TEF and FBP1. A Venn diagram of DE miRNAs and prognostic miRNAs. B Bar plot of ImmuLncRNA NES of miRNAs which targeted PGNG. The color indicated the regulation of each miRNA to PGNG, with the condition of enriched (red) or suppressed (blue). C KM plot of miR-4477b. The group was determined by median value of miR-4477b expression. D Boxplot of miR-4477b among different tumor stages. The stages II, III, and IV were compared to I, respectively. E Pearson correlation heatmap of miR-4477b and PGNG genes. F Dot plot of miR-4477b targeted TFs. The color indicated the correlation condition of TFs with miR-4477b. G Network of TEF and predicted targeted PGNG genes. H The predicted binding sites between miR-4477b and the 3′ UTR of TEF mRNA. *P < 0.05, **P < 0.01, ***P < 0.001

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Cancer & Metabolism

ISSN: 2049-3002