Fig. 1

The expression of BMP4 and SLC2A1 is elevated and positively correlated in HCC. A Comparative analysis of the expression of BMP4 between tumor tissues (T, n = 369) and adjacent non-tumorous liver tissues (N, n = 160) from TCGA. *P < 0.05, T group vs. N group. B IHC staining analysis of BMP4 protein expression and PAS staining in HCC tissues and adjacent non-tumorous liver tissue (Para-CA) of 40-paried patient samples. Positive staining was indicated by arrows. C The scores of IHC of BMP4 and PAS in B were judged by degree and range of positive staining. *P < 0.05, HCC group vs. para-Ca group. D Comparative analysis of the expression of SLC2A1, SLC2A2, SLC2A3, and SLC2A4 between tumor tissues (T, n = 369) and adjacent non-tumorous liver tissues (N, n = 160) from TCGA. *P < 0.05, T group vs. N group. E Violin plot analysis of the SLC2A1 expression level from stage I to stage IV in LIHC from TCGA. F The overall survival time of HCC patients related to SLC2A1 was analyzed by Kaplan-Meier survival analysis from TCGA. G IHC staining of SLC2A1 expression in HCC tissues and adjacent non-tumorous liver tissue (para-CA) of 40 paired HCC specimens. Positive staining was indicated by arrows. H The scores of IHC were judged by degree and range of positive staining. *P < 0.05, HCC group vs. para-Ca group. I Pearson’s correlation analysis of IHC scores results between BMP4 and SLC2A1 expression of 40 paired HCC specimens (**P < 0.01). J Pearson’s correlation analysis between Bmp4 and SLC2A1 mRNA expression from GTE