Obesity and breast cancer prognosis: pre-diagnostic anthropometric measures in relation to patient, tumor, and treatment characteristics

Table 2 Survival estimates of recurrence and mortality according to body mass index, waist circumference, and body fat percentage in 1099 patients with incident invasive breast cancer in the Malmö Diet and Cancer Study

Endpoint	Body composition	No. of patients	Events	Unadjusted HR (95%CI)	Adjusted HR^a (95%CI)
Body mass index
Recurrence	Healthy weight	556	129	(ref)	(ref)
	Overweight	384	92	1.17 (0.89–1.54)	1.23 (0.86–1.76)
	Obesity	159	42	1.39 (0.98–1.99)	1.56 (1.00–2.46)
Mortality	Healthy weight	556	166	(ref)	(ref)
	Overweight	384	160	1.57 (1.26–1.96)	1.18 (0.88–1.59)
	Obesity	159	72	1.73 (1.31–2.29)	1.51 (1.05–2.18)
Waist circumference
Recurrence	Healthy weight	723	166	(ref)	(ref)
	Overweight	119	33	1.34 (0.92–1.95)	1.18 (0.73–1.90)
	Obesity	223	59	1.35 (1.01–1.83)	1.46 (1.00–2.13)
Mortality	Healthy weight	723	229	(ref)	(ref)
	Overweight	119	45	1.26 (0.92–1.74)	1.03 (0.67–1.58)
	Obesity	223	113	1.71 (1.36–2.15)	1.45 (1.07–1.96)
Body fat percentage
Recurrence	Healthy weight	109	31	(ref)	(ref)
	Overweight	476	101	0.96 (0.58–1.59)	0.99 (0.53–1.85)
	Obesity	514	131	1.25 (0.76–2.04)	1.41 (1.02–1.98)
Mortality	Healthy weight	109	31	(ref)	(ref)
	Overweight	476	151	1.39 (0.86–2.24)	1.25 (0.71–2.20)
	Obesity	514	216	1.97 (1.23–3.14)	1.30 (0.74–2.27)

^aAge, histological grade, tumor size, nodal status, estrogen-receptor status, surgery, planned adjuvant radio-, chemo-, and endocrine therapy
^bHR Hazard ratio, CI Confidence interval

ISSN: 2049-3002