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Fig. 3 | Cancer & Metabolism

Fig. 3

From: Blocking lncRNA-SNHG16 sensitizes gastric cancer cells to 5-Fu through targeting the miR-506-3p-PTBP1-mediated glucose metabolism

Fig. 3

5-Fu-resistant gastric cancer cells display glucose addictive phenotype. a ECAR, b glucose uptake, and c glycolysis enzymes were measured in AGS parental and 5-Fu-resistant cells. d AGS parental and 5-Fu-resistant cells were cultured under normal or low glucose conditions. Cell viability was determined by clonogenic assay. e The above cells under normal or low glucose conditions were treated with 5-Fu for 48 h. Cell viability was determined by clonogenic assay. f, g, h AGS 5-Fu-resistant cells were treated with 5-Fu alone or combined with glycolysis inhibitors at the indicated concentrations. Cell death was determined by MTT assay and Annexin V apoptosis assay. Data were presented as mean±S.D. *p<0.05; **p<0.01; ***p<0.001

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Cancer & Metabolism

ISSN: 2049-3002