Skip to main content
Fig. 7 | Cancer & Metabolism

Fig. 7

From: Dynamic regulation of mitochondrial pyruvate metabolism is necessary for orthotopic pancreatic tumor growth

Fig. 7

PDHA1 regulation and PDHK1 are essential for optimal growth of orthotopic pancreatic tumors. 106 of the indicated cells were injected into the pancreas of immune-deficient mice. Tumor mass was calculated by taking the mass of the pancreas and spleen and subtracting 0.1 g for normal tissue. A Image of excised orthotopic tumors in the pancreas (inferior) and spleen (superior). B Individual pancreas masses from the indicated knockout MiaPaca2 cells 4 weeks after implantation. P = 0.003 by ANOVA. C Individual pancreas masses from tumors grown from PDHA1 mutant expressing MiaPaca2 cells 8 weeks after implantation as calculated in B. P = 0.029 by ANOVA

Back to article page

Cancer & Metabolism

ISSN: 2049-3002