The effect of metabolic syndrome on head and neck cancer incidence risk: a population-based prospective cohort study

Table 3 Linear associations for MS components related to head and neck cancer risk

MS components	Model 1		Model 2		Model 3
MS components	HR (95% CI)	P	HR (95% CI)	P	HR (95% CI)	P
Waist circumference^a	1.43[1.34, 1.53]	<0.001	1.16[1.07, 1.25]	<0.001	1.09[1.01, 1.18]	0.032
Waist circumference (male)	1.19[1.10, 1.28]	<0.001	1.19[1.10, 1.28]	<0.001	1.10[1.02, 1.20]	0.019
Waist circumference (female)^b	0.98[0.85, 1.13]	0.788	0.98[0.85, 1.13]	0.796	0.95[0.82, 1.10]	0.490
HDL-C^a	0.78[0.72, 0.84]	<0.001	1.02[0.93, 1.11]	0.723	1.07[0.98, 1.17]	0.098
HDL-C (male)^b	1.01[0.93, 1.10]	0.801	1.01[0.93, 1.10]	0.783	1.05[0.97, 1.15]	0.243
HDL-C (female)^b	1.02[0.87, 1.18]	0.830	1.02[0.88, 1.18]	0.821	1.08[0.92, 1.27]	0.329
Blood glucose^b	1.09[1.03, 1.15]	0.002	1.07[1.01, 1.13]	0.018	1.06[1.01, 1.12]	0.032
Diastolic blood pressure^b	1.07[1.00, 1.05]	0.043	0.99[0.92, 1.06]	0.716	0.99[0.93, 1.07]	0.848
Systolic blood pressure	1.09[1.01, 1.17]	0.018	1.03[0.96, 1.11]	0.415	1.03[0.96, 1.10]	0.451
Triglycerides (mmol/L)	1.12[1.05, 1.20]	<0.001	1.03[0.97, 1.11]	0.339	0.97[0.91, 1.04]	0.407

Model 1: unadjusted
Model 2: age and gender-stratified model
Model 3: additionally adjusted for education, ethnic, index of multiple deprivation, alcohol consumption, smoking status, physical activity, fruit and vegetable intake, NASIDS use and CRP
^aMS component with sex-specific definition
^bU-shaped association MS components related to head and neck cancer risk in non-linear spline models

ISSN: 2049-3002