From: Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma
Anaplerotic substrates | D423 | N | Concentrations |
---|---|---|---|
ENO1 deleted | in Human Blood (μM) | ||
Pyruvate Free | 22 | 12 | Â |
100 μM Pyruvate | 28 | 6 | 35 |
1 mM Pyruvate | 51 | 6 | 35 |
5 mM Pyruvate | 49 | 6 | 35 |
2.5 mM Methyl Pyruvate | 133 | 4 | N/A |
5 mM dimethyl 2-oxoglutarate | 189 | 2 | N/A |
5 mM Lactate | 19 | 4 | 1,118-1,860 |
5 mM Acetate | 19 | 2 | 27-64 |
5 mM Alanine | 11 | 2 | 427 |
2.5 mM Aspartate | 29 | 2 | 8-20 |
1X B27 | 36 | 2 | N/A |
1X Fatty Acid | 39 | 2 | N/A |
2.5 mM Oxaloacetate | 87 | 4 | N/A |
2.5 mM Oxovalerate | 60 | 4 | 13 |